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1、徐建波,等肝細胞肝癌血清AFP值與HBV感染的關系消化·泌尿系腫瘤專肝細胞肝癌血清AFP值與HBV感染的關系徐建波,祁付珍,魏天翼,時汀,許剛,張建淮RelationshipbetweenserumAFPIevelandHBVii1patientswithhepatocellularcarcinomaXuJianbo,QiFuzhen,WeiTianyi,ShiTin,XuGang,ZhangJianhuaiDepartmentofGeneralSurgery,Huai~mFirstPeople'sHospital,NanfingMedicalUniversity,JiangsuHua
2、i'an223300,China.【AbstractlObjective:ToinvestigatetherelationshipbetweenserumAFPlevelandHBVofHCCpatients.Meth·ods:Aretrospectivestudywasconductedonpatientswhowerediagnosedwithlivermalignantneoplasmandreceived.surgerytreatmentfromJanuary,2009toJune,2011.Results:Atotalof217patientswithlivermaligna
3、ntneoplasmwereenrolledinthisstudyincluding176hepatocellularcarcinoma(HCC)patientsand41otherlivertumorpatients.InHCCpatientswithHBVinfection,thefirstthreeofHBV—infectionmodelbeingHBsAg,HBeAbandHBcAbposi—tive(secondarythreepositive),HBsAgandHBcAbpositiveandHBsAg,HBeAgandHBcAb(mainthreepositive)wit
4、h30.7%.25.6%and20.5%respectively.HCCpatientsshowedasignificantlyhigherserumAFPlevelsthanoth—erlivetumorpatients(P<0.001).However,inHCCgroup,HBVinfectiondidnotaffecttheprobabilityofshowinganelevatedAFP(P:0.147),andtherewasnosignificantdifferenceamongpatientswithsecondarythreepositive,HBsAgandHBcA
5、bpositiveandmainthreepositive(P=0.578).Similarly,thetopthreeHBV—infectionmodelsdidnotaffectthelevelsofseI'umAFPregardlessofAFPnegativeorAFPpositive.Conclusion:HCCpatientshaveasig—nificantlyhigherserumAFPlevelsthanotherlivetumorpatients,butthereisnosignificantrelationbetweenAFPlev·elsandHBV—infec
6、tionmodels.【Keywords】hepatocellularcarcinoma;hepatitisvirusB;alpha—fetoprotein(AFP)ModeruOncology2014,22(12):2900—2902【摘要】目的:探索肝細胞肝癌患者血清AFP值與HBV感染模式的關系。方法:回顧性分析2009年1月到2011年6月于我院就診并手術的所有肝臟惡性腫瘤患者的臨床資料。結果:共有217例肝臟惡性腫瘤患者納入研究:肝細胞肝癌(HCC)組176例,非HCC組41例。HCC組中HBV感染模式前三位的分別是HBsAg,HBeAb和HBcAb陽性(小三陽)(30.7%
7、),HBsAg和HBcAb陽性(25.6%)及HBsAg,HBeAg和HBcAb陽性(大三陽)(20.5%)。HCC組血清AFP值高于非HCC組血清AFP值(P<0.001),但HCC組內HBV感染組與非HBV感染組之間血清AFP水平無統(tǒng)計學差異(P=0.147),三種主要HBV感染模式之間血清AFP值也無統(tǒng)計學差異(P=0.578)。同樣的,無論在AFP陰性組(<20ng/m1)還是AFP陽性組(~>20ng/m1),三種主要的HBV感染模式