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1、中華中醫(yī)藥雜志(原中國(guó)醫(yī)藥學(xué)~)2013年10月第28卷第10期CJTCMP,October2013,Vo1.28,No.10‘3101·activityandimmunityinpatientswithundiferentiatedsomatoform應(yīng)用進(jìn)展.中華中醫(yī)藥雜志,2011,26f71:1574—1577disorder.PsychiatryResearch:Neuroimaging,2012,202(4):252—256ZENGLi,YANGJian—hua.Studyonwoundrepairmechanismof【5]MikaH,TeroV,Pa
2、ivimN,eta1.Brainglucosemetabolismandtetramethylpyrazineandtheprogressinclinicalapplication.Chinatemperamentinrelationtoseveresomatization.PsychiatryandJournalofTraditionalChineseMedicineandPharmacy,2011,ClinicalNeurosciences,2006,60(5):669—67526:1574—1577f61曾莉,楊建華川芎嗪創(chuàng)傷修復(fù)相關(guān)性作用機(jī)制研究及臨床(收稿
3、日期:2012年11月2日)·研究報(bào)告·天舒膠囊治療肝陽(yáng)上亢型偏頭痛的臨床療效及作用機(jī)制丁硯兵,明淑萍,楊晨(湖北省中醫(yī)院,武漢430061;湖北中醫(yī)藥大學(xué),武漢430061)摘要:目的:觀察天舒膠囊治療肝陽(yáng)上亢型偏頭痛的臨床療效,探討其作用機(jī)制。方法:將60例肝陽(yáng)上亢型偏頭痛患者隨機(jī)分為兩組,每組30例,治療組給予天舒膠囊治療,對(duì)照組給予西比靈膠囊治療,療程1個(gè)月。觀察兩組的臨床療效和血小板、血液流變學(xué)指標(biāo)及5一羥色胺(5-HT)、一氧化氮(NO)含量的變化。結(jié)果:治療組偏頭痛患者的頭痛癥狀及中醫(yī)證候明顯改善,與對(duì)照組相比均有顯著性差異(P<0.O1)。治療組治療
4、后血小板與血液流變學(xué)指標(biāo)及5.HT、NO含量與治療前比較均顯著性下降(P<0.05)。結(jié)論:天舒膠囊治療肝陽(yáng)上亢型偏頭痛有明顯臨床療效。天舒膠囊能抑制血小板聚集,降低全血黏度,對(duì)抗血管活性物質(zhì)和神經(jīng)遞質(zhì)水平的失常,調(diào)節(jié)腦及血管功能紊亂,這可能是其治療偏頭痛的作用機(jī)制之一。關(guān)鍵詞:偏頭痛;天舒膠囊;血小板;血液流變學(xué);5-羥色胺;一氧化氮TherapeuticeffectsandmechanismofTianshuCapsuleintreatmentofpatientswithmigraineofliveryanghyperactivityDINGYan—bing,M
5、INGShu—ping,YANGChen(HubeiProvinceTraditionChineseMedicalHospital,Wuhan430061,China;HubeiUniversityofChineseMedicine,Wuhan430061,China)Abstract:ONective:ToobservethetherapeuticeffectsofTianshuCapsuleinthetreatmentofpatientswithmigraineandinvestigateitsmechanism.Methods:Sixtypatientswit
6、hmigraineofliveryanghyperactivityweredividedrandomlyintotwogroups,witheachof30cases.ThetreatmentgroupwasgivenTianshuCapsuleandthecontrolgroupwasgivenSibeliumCapsule.Thetotalcoursewasonemonth.Thetherapeuticeffectsandthechangesofbloodplatelet,hemorheologicalparameters,5一HTandNOwereobserv
7、edintwogroups.Results:ThetreatmentgroupcanrelieveheadachesandimprovethesyndromeoftraditionalChinesemedicine.Comparedwiththecontrolgroup,thetreatmentgroupwassignificantdifference(P<0.01).Thechangesofbloodplatelet,hemorheologicalparameters,5-HTandNOweresignificantlydecreasedaftertreatm