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1、孟德爾隨機(jī)化分析原理解析StandardizedplaninMendelianrandomisationstudyExtractinterestingSNPsExtractdataofcasesandcontrolsTwo-sampleMRPotentialproblemsandlimitationsofMendelianrandomisationstudyValidateSNPsExtractinterestingSNPsPvalue<5×10?81.SUNLIGHTConsortium,CanadianMulticentreOsteoporosisStud
2、y(CaMos)2.FromthelargestGWA(UKBiobank)3.FromtheGIANT(GeneticInvestigationofAnthropometricTraits)consortiumeg.BMI,HeightExtractdataofcasesandcontrolsUKBiobankAsthma,hildrenAsthma(GABRIELconsortium)Atopicdermatitis(EAGLEEczemaConsortium)IgElevels(GABRIELconsortium)EarlyGeneticsandLife
3、courseEpidemiology(EAGLE)EczemaConsortium@HavethedetailinformationofinterestedSNPsincasesandcontrolsTwo-sampleMREg.Therelationshipbetweengeneticvariantsand25OHDwasascertainedfromonestudy,andtherelationshipbetweenthesamegeneticvariantsandAsthma,Childhoodasthma,Atopicdermatitis,IgEwas
4、ascertainedfromasecondstudy.Waldratios(βIV)=βZY/βZXβZXSNP與暴露或中間表現(xiàn)的相關(guān)系數(shù)βZYSNP與目標(biāo)結(jié)局的相關(guān)系數(shù)ValidateSNPs5.敏感性分析(依次剔除功能相似,在同一基因上或附近的SNPs)驗(yàn)證MR三個(gè)假設(shè)(線性回歸,Logistic回歸,meta分析)分析SNPs與中間表型的相關(guān)性(+)分析SNPs與已知混雜因素的相關(guān)性(-)目標(biāo)SNPs對(duì)結(jié)局的作用必須只能通過已知的研究表型PotentialproblemsandlimitationsofMendelianrandomisationstu
5、dyNon-linearassociationsWeakinstrumentsLinkagedisequilibriumPopulationstratificationundertakesubgroupanalyses6.Don’ttogainmechanisticinsights操作演示此課件下載可自行編輯修改,僅供參考!感謝您的支持,我們努力做得更好!謝謝