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1、BritishJournalofHaematology,1990,76,Suppl.2,24-26PreventionofGram-positiveandCandidaalbicansinfectionsusingteicoplaninandfluconazole:arandomizedstudyinneutropenicchildrenG.SCHAISON,A.BARUCHELANDG.ARLETSaint-LouisHospital,DepartmentofPediatricHaematology,Paris,FranceSummary.Wehaveshownthatthecomb
2、inationofteicopla-Bwasusedinfebrilerelapses.Forty-sixpatientswereeligiblenin(T)andceftriaxone(C)givenoncedailyasfirst-line(23ineacharm:nostatisticallysignificantdifferencesempiricalantimicrobialtherapyisveryeffective(85%)andbetweenthetwogroups).Themeanageofthepatientswas8safeinfebrileneutropenic
3、children(ICAAC.1988).Likeyearsandmeandurationofaplasia23and24d.Resultswereothers(ICAAC.1989)wehavestressedthenewIife-asfollows:armAthedurationofT+Falonewas10d,22threateningproblemswithStreptococcusrnitisandStrep.patientshadafebrileepisodewith1Gram-positive,11Gram-sunguis.Consideringtheregularsen
4、sitivityofGram-positivenegativeandonecandidastrainisolatedineightpatients.organismstoT.itispossiblethattheintroductionoftheC+Awereeffectivein72%ofthesepatients.Therewerenoglycopeptideattheonsetofaplasiamaybehelpful.Thehighdeaths.InarmB,feveroccurredinallpatientsduringthefirstincidenceoffungalinf
5、ectionorsuperinfectionsupportsthe6d,witheightGram-positiveandsixGram-negativeorga-routineuseofaneffectiveantifungalagentwhenfeverisstillnismsisolatedinninepatients.presentorrelapseoccurs.C+T+Aweresuccessfulin83%ofpatients.AbacterialOurstudywasdesignedtoassessthepreventionof(I)superinfectionwasdo
6、cumentedinfourpatients,candidastaphylococcalandstreptococcalinfectionsusingTwhenthesuperinfectioninsevenpatientsandonepatientdiedfromcentralcatheterisbeingplaced,and(2)candidainfectionbyCundidapurukruseisepticaemia.WhenthetotalamountofCthesimultaneoususeofanewanti-mycoticagentfluconazoleandAused
7、inbotharmswascompared,therewasa(F)administeredonce-daily.Patientswererandomizedintoreductionin20%ofthetwoagentsinarmA,butTwastwoarmsofthestudy.ArmAreceivedT6mg/kg/dandF3equivalentinbotharms.Treatmentwaswelltoleratedinmg/kg/d
