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《重復(fù)經(jīng)顱磁刺激聯(lián)合氟西汀治療老年抑郁癥的臨床對(duì)照研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫(kù)。
1、重復(fù)經(jīng)顱磁刺激聯(lián)合氟西汀治療老年抑郁癥的臨床對(duì)照研宄茅衛(wèi)兵江飛朱圣潔徐健(南通市第四人民醫(yī)院江蘇南通226005)FI的：探討rTMS治療老年抑郁癥首次發(fā)病患者的有效性及安全性。方法：采用隨機(jī)、單盲對(duì)照法，將63例年齡大于60歲的抑郁癥首發(fā)患者分為rTMS組和氟西汀組，兩組均服用氟西汀20mg/d，rTMS組加用6周rTMS真性刺激，以10Hz、90%運(yùn)動(dòng)閾值刺激患者左前額葉背外側(cè)，氟西汀組加用6周rTMS偽刺激治療。治療前后用漢密頓抑郁量表(HAMD-17)和副反應(yīng)量表(TESS)評(píng)價(jià)療效和不良反應(yīng)。結(jié)果：實(shí)際完成
2、觀察63例，其屮rTMS組31例，氟西汀組32例。治療第1周末，rTMS組的HAMD總分較治療前明顯卜降(P<0.01),有效率及減分率均高于氟西汀組(P<0.05)。氟西汀組HAMD總分在治療第2周末較治療前明顯下降(P<0.01);治療第1,2周末，rTMS組有效率高于氟西汀組，組間差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療第4,6周末，rTMS組治愈率高于氟西汀組，組間差異均有統(tǒng)計(jì)學(xué)意義(P<0.05),而兩組有效率的差異無(wú)統(tǒng)計(jì)學(xué)意義(P>O.05)。兩組患者出現(xiàn)藥物不良反應(yīng)者各4例，差異無(wú)統(tǒng)計(jì)學(xué)意義(P&
3、gt;O.05)。結(jié)論:rTMS聯(lián)合氟西汀治療老年首發(fā)抑郁癥患者起效較快、安全、療效肯定,治愈率更高。【關(guān)鍵詞】抑郁癥；老年人；氟西??；重復(fù)經(jīng)顱磁刺激【屮圖分類號(hào)】R453A1007-8231(2016)09-0037-03Theefficacyandtolerabilitylofrepetitivetranseranialmagneticstimulation(rTMS)combinedwithfluoxetineintreatmentofelderlypatientswithfirst-episodedepres
4、sionMaoWeibing,JiangFei,ZhuShengjie,XuJian.TheForthHospitalofNantong,Nantong226005,China[Abstract]ObjectiveTostudytheefficacyandsafetyofrepetitivetranseranialmagneticstimulation(rTMS)combinedwithfluoxetineintreatingtheelderlypatientswithfirst-episodedepression.
5、MethodsArandom,singleblindstudywasconductedin63first-episodedepressivepatientsaged60yearsorover.Thepatientswereassignedtofluoxetinetreatment(20mg/d)incombinationwithasix-weekperiodofeitherrTMS(rTMSgroup)orshamprocedure(fIuoxetinegroup)onleftdorsolateralprefront
6、cortex(10Hz,90%motorthreshold).Theefficacywasevaluatedwiththehumiltonratingscalefordepression(HAMD).ThesafetyprofileswereassessedwithTESS.Results63caseswerefinishedthestudy.Attheendofweeks1,significantlymoreHAMDscorereductionwasinrTMSgroupthaninfluoxetinegroup.
7、Atweeks1and2,theresponseratesinrTMSgroupweresignificantlyhigherthanfluoxetinegroup(P<0.01).Atweeks4and6,theremissionratesinrTMSgroupweresignificantlyhigherthanfluoxetinegroup(P<0.01),theresponserateswerenotsignificant(P>0.05).ConclusionrTMSisanewoptionforthe
8、elderlydepressionpatients.【Keywords]Depression;Aged;Fluoxetine;Repetitivetranseranialmagneticstimulation(rTMS)隨著社會(huì)的老齡化，老年人U不斷增加，老年抑郁癥的患病率也呈現(xiàn)上升趨勢(shì)，這引起了醫(yī)學(xué)界的廣泛重視和關(guān)注。選擇性5-羥色胺再攝取抑
