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1、順鉑+IL-2胸腔內(nèi)灌注治療老年晚期肺腺癌惡性胸腔積液【摘要】目的:觀察順鉑+il-2胸腔內(nèi)灌注聯(lián)合培美曲塞全身化療治療老年晚期肺腺癌惡性胸腔積液的臨床療效及毒副反應(yīng)。方法:老年肺腺癌并胸腔積液患者共51例,采用順鉑40mg/m2及il-2150萬u胸腔灌注保留,每周一次,共2周,同時應(yīng)用培美曲塞,第1天,每3周重復(fù),完成2個周期。治療第4周評價療效及毒副作用。結(jié)果:51例患者均可評價療效,完全緩解者16例,部分緩解者25例,無效者6例,其有效率為80.39%,完全緩解率31.37%。結(jié)論:順鉑+il-2胸腔內(nèi)灌注聯(lián)合培美曲
2、塞全身化療治療老年晚期肺腺癌惡性胸腔積液治療的方法療效顯著,毒性反應(yīng)輕,臨床使用安全?!娟P(guān)鍵詞】順鉑;il-2;培美曲塞;老年;肺腺癌;胸腔積液clinicalobservationofcisplatin+il-2intrathoracicperfusionjointpemetrexeddisodiumsystemicchemotherapyforelderlypatientswithadvancedmalignantpleuraleffusionoflungcancer/wangyong-ming,jingli-jun,f
3、enggui-xin,etal.//medicalinnovationofchina,2012,9(31):018-019【abstract】objective:observationoncisplatinandil-2intrathoracicperfusioncombinedwithpemetrexeddisodiumsystemicchemotherapyforelderlypatientswithadvancedmalignantpleuraleffusionoflungadenocarcinoma’sclinica
4、lefficacyandsideeffects.method:thelungadenocarcinomainelderlypatientswithpleuraleffusionatotalof51cases,theintrathoracicinjectionofcisplatin(40mg/m2)andil-2(1.5millionu)onceaweekfor2weeksweregiven.atthesametime,pemetrexeddisodiumforinjection(500mg/m2),thefirstday,e
5、very3weeksrepeated,twocycles.the4thweekforevaluatingefficacyandsideeffects.result:51patientscouldbeevaluatedtheeffects,16caseswerecompletelyalleviated,apartofthemitigationin25cases,6casesineffective.thenitseffectiverateof80.39%,completeremissionrate31.37%.conclusio
6、n:cisplatinandil-2intrathoracicperfusioncombinedwithpemetrexeddisodiumsystemicchemotherapyisaeffectivetreatmentmethodforelderlylungadenocarcinomapatientswithadvancedmalignantpleuraleffusionwhichwerelighttoxicityandsafeclinicaluse.【keywords】cisplatin;il-2;pemetrexed
7、disodium;elderly;lungadenocarcinoma;pleuraleffusionfirst-author’saddress:no.2people’shospitalofweifanginshandong,weifang261041,chinadoi:10.3969/j.issn.1674-4985.2012.31.008惡性胸腔積液是晚期惡性腫瘤的常見并發(fā)癥,臨床表現(xiàn)為胸悶、呼吸困難、心慌、胸痛等癥狀,嚴(yán)重影響患者的生活質(zhì)量。因此,有效地控制胸腔積液能更好地提高生活質(zhì)量,延長生存期,在晚期腫瘤治療中起著
8、重要作用。常用的治療方法是胸腔閉式引流及胸腔內(nèi)局部給藥。但是,臨床效果常不能令人滿意,短期內(nèi)胸水又再次出現(xiàn),反復(fù)胸穿給患者帶來很大痛苦;雖然提高劑量可增加療效,但化療副反應(yīng)增大,大多數(shù)患者難以耐受。本文通過順鉑+il-2胸腔內(nèi)灌注聯(lián)合培美曲塞全身化療治療老年晚期肺腺癌惡性胸腔積液,效果較好