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1、冷循環(huán)射頻與手術(shù)治療肝癌的臨床研究【摘要】目的研究比較冷循環(huán)射頻與手術(shù)治療肝癌的療效、并發(fā)癥情況、住院花費(fèi)、住院天數(shù)及生活質(zhì)量。方法肝癌患者159例,分為兩組:腫瘤直徑≤5.0cm、單發(fā)腫瘤44例,手術(shù)治療29例,冷循環(huán)射頻治療15例;腫瘤直徑>5.0cm患者115例,手術(shù)治療54例,冷循環(huán)射頻治療61例。冷循環(huán)射頻治療采用Col-tipRFTM系統(tǒng),于超聲引導(dǎo)下將集束射頻治療針穿刺進(jìn)入腫瘤進(jìn)行治療。分組比較兩種治療的肝功能、AFP改變、并發(fā)癥情況、住院天數(shù)及花費(fèi)、生活質(zhì)量評(píng)分等。描述影像學(xué)變化。結(jié)果冷循環(huán)射頻治
2、療對(duì)患者肝臟功能的破壞小于手術(shù)治療。冷循環(huán)射頻治療和手術(shù)治療對(duì)患者AFP水平的影響沒有明顯差異。冷循環(huán)射頻治療并發(fā)癥發(fā)生率,住院天數(shù)及花費(fèi)低于手術(shù)治療,術(shù)后生存質(zhì)量高于手術(shù)治療。腫瘤直徑≤5.0cm、單發(fā)腫瘤,冷循環(huán)射頻和手術(shù)1年生存率及中位生存時(shí)間沒有差異。結(jié)論相對(duì)于手術(shù),冷循環(huán)射頻治療也是一種安全,有效的肝癌治療方法?!娟P(guān)鍵詞】射頻手術(shù)肝癌生活質(zhì)量Clinicalstudyoftheapplicationofradiofrequencyablationandoperationontreatmentoflive
3、rcancer【Abstract】ObjectiveToprobeintothetreatment15effect,complicationsrate,lifequalityandhospitalizationexpensesofapplyingradiofrequencyablation(RFA)totreatlivercancerandcomparetowhichoftheoperation.Methods159livercancerpatientswereincludedinthisstudy.Theywe
4、redividedintotwogroupsaccordingtothediametersoftheirtumorsandwhethertheirtumorsweresolo.Among44casesinthegroupofsolotumorwithtumordiametersequalandlessthan5.0cm,29casesreceivedoperationsand15receivedradiofrequencytreatments,among115casesofthegroupwithtumourdi
5、ametersmorethan5.0cm,54casesreceivedoperationsand61receivedradiofrequencytreatments.Theoperationswerehepatolobectomy.Radiofrequencytreatmentwereconductedeitherpercutaneouslyorintraoperativelyundertheguidanceofultrasound.Thebundledneedleswerepuncturedintothetu
6、morsandperformedradiofrequencytreatments,withtreatmentfrequencyof480kHz,treatmenttime12min.Collecteddataofliverfunction(ALT,ALB,TB),AFP,complications,hospitalizationdaysandexpensesofpatientsreceivingoperationsandradiofrequencytreatmentsrespectively,observedch
7、angesinradiology.Differencesbetweentheabove-mentioneddataofpatientsreceivedoperationsandradiofrequencytreatmentswithintwogroupswerecompared.Results15Thedamagingeffectofliverfunctionofradiofrequencytreatmentwaslessseverethanoperations.Therewasnosignificantdiff
8、erencebetweentheAFPchangesofpatientsreceivedradiofrequencytreatmentandthosereceivedoperations.Concerningcomplications,hospitalizationdaysandexpenses,situationsofpatientsreceivedradiofrequ