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1、腦鈉肽及冠脈造影病變關(guān)系探究作者：鄧新桃，石桂良，鄭金國(guó)，趙建祥，洪淵，馬根山【摘要】目的：觀察血清腦鈉肽(BNP)濃度的變化與冠脈病變之間的關(guān)系。方法：臨床擬診冠心病患者374例，按冠脈造影結(jié)果分為陽(yáng)性組(235例)、陰性組(139例)，并根據(jù)冠狀動(dòng)脈病變的范圍分為單支血管病變組(64例)、雙支血管病變組(79例)和三支血管病變組(92例)，均于入院時(shí)測(cè)定血清中BNP、C反應(yīng)蛋白(CRP)水平，進(jìn)行統(tǒng)計(jì)分析。結(jié)果:陽(yáng)性組BNP濃度為(115.91±53.64)pg/ml,陰性組(37.70±33.61)pg/ml,兩組間差異有統(tǒng)計(jì)學(xué)
2、意義,P<；0.01；單支病變組濃度為(96.49±12.09)pg/ml>雙支病變組濃度為(113.49±11.94)pg/ml.三支病變組濃度為(121.80±9.77)pg/ml,單因素方差分析示組間差異有統(tǒng)計(jì)學(xué)意義，P<；0.05；多因素Logistic分析結(jié)果示BNP水平與冠脈造影(CAG)診斷冠心病(CHD)結(jié)果明顯相關(guān)。結(jié)論：血清BNP水平是冠心病的獨(dú)立危險(xiǎn)因素，其水平的增高對(duì)冠心病患者病變累及的程度可能有一定臨床參考價(jià)值，且BNP是較CRP更敏感的指標(biāo)?！娟P(guān)鍵詞】腦鈉肽；C反應(yīng)蛋白；冠心??；冠狀動(dòng)脈造影[Abs
3、tract]Objective：Toinvestigatetherelationshipbetweentheserumbrainnatriureticpeptide(BNP)concentrationvariancesandcoronaryangiographydisease?Methods：AccordingtotheresuItsofcoronaryangiography,374casesweredividedintoCHDgroup(235cases)andtheNonCHDgroup(139cases).Accordingto
4、thescopeofcoronaryarterydisease,theCHDgroupweredividedintosinglevesseldiseasegroup(64cases),doublevesseldiseasegroup(79cases)andthreevesseldiseasegroup(92cases).AllcaseswererespectivelymeasuredserumBNPandCRPlevelsonadmission,thenanalyzed.ResuIts：LevelsofserumBNPoftheCHD
5、group(115.91±53.64)pg/mlweresignificantlyelevatedcomparedwithNonCHDgroup(37.70±33.61)pg/ml,P<；0.01.LevelsofserumBNPofthesinglevesseldiseasegroupis(96?49±12.09)pg/ml,doublevesseldiseasegroup(113.49±11.94)pg/ml,threelesions(121.80+9.77)pg/ml?OnewayANOVAshowedsignificant
6、differencesamonggroups,P&It；0.05.MultinomiallogisticanalysisshowedBNPlevelssignificantlycorrelatedCHD.Conelusion：SerumBNPlevelwasanindependentriskfactorforcoronaryheartdisease?TheirlevelsincreasedinCHDpatientsmayhavesomedegreeofclinicalreferencevalueforlesionsinvolvingt
7、heextentofcoronaryartery,andBNPwasamoresensitiveindicatorthanCRP?_Keywords]brainnatriureticpeptide；Creactiveprotein；coronaryheartdisease；coronaryangiography冠心病的各種危險(xiǎn)因素不斷地被發(fā)現(xiàn)和證明，且均已成為預(yù)防和治療冠心病的關(guān)鍵靶點(diǎn)。腦鈉肽(brainnatriureticpeptide,BNP)與心血管疾病的關(guān)系以及作用機(jī)制正成為近年研究的熱點(diǎn)。C反應(yīng)蛋白(Creactivepr
8、oteinCRP)水平的升高和造影所示冠脈病變數(shù)相關(guān)，病變數(shù)越多，血CRP水平越高。本研究測(cè)定冠心病患者血漿BNP、CRP水平，旨在探討它們對(duì)冠心病短期預(yù)后的預(yù)測(cè)價(jià)值及兩者之間的相關(guān)性，為評(píng)價(jià)冠心病的病情提供新的理論依據(jù)
