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1、CurrentstatusofgenetherapyformotorneurondiseaseNeuralRegenResISSN1673.5374CN11-5422/RAugust252006Vol1No5SpecialTopicsandReviewCurrentstatusofgenetherapyformotorneurondiseaseXingkaiAn,RongPeng,ShanshanZhaoAbstractOBJECTIVE:Althoughtheetiologyandpathogenes
2、isofmotorneurondiseaseisstillunknownttherearemanyhypothesesonmotorneuronmitochondrion,cytoskeletonstructureandfunctionalinjuries-Thustgenetherapyofmotorneurondiseasehasbecomeahottopictoapplyinviralvectors,genedeliveryandbasicgenetechniquesDATASOURCES:The
3、relatedarticlespublishedbetweenJanuary2000andOctober2006weresearchedinMedlinedatabaseandISIdatabasebycomputerusingthekeywords"motorneurondisease,genetherapy",andthelanguageislimitedtoEnglish,Meanwhile,therelatedreferencesofreviewwerealsosearchedbyhandiwo
4、rk.STUDYSELECTION:Originalarticlesandreferredarticlesinreviewwerechosenafterfirsthearing,thenthefulltextwhichhadnewideaswerefound,andwhenrefertothesimilarstudyintherecentyearswereconsid-eredfirstDATAEXTRACTION:Amongthe92relatedarticles,40oneswereaccepted
5、.and52wereexcludedbecauseofrepetitivestudyorreviews.DATASYNTHESIS:Theviralvectorsofgenetherapyformotorneurondiseaseincludeadenoviral,adeno-as-sociatedviralvectors.herpessimplexvirustype1vectorsandlentiviralvectorsThedeliveryofthemcanbeachievedbydirectinj
6、ectionintothebrain.orbvremotedeliveryafterinjectionvectorsintomuscleorperipheralnerves.orbyexvivogenetransfer.Theviralvectorsofgenetherapyformotorneurondiseasehavebeensucocessfullydeveloped.butthegenedeliveryofthemishamperedbysomedifficulties.TheRNAinter
7、ferenceandneur0Or0tecti0narethemaintechnologiesforgene-basedtherapyinmotorneurondisease'DepartmentofNeurology.WestChinaHospital,SichuanUniver-sityChengdu610041,SichuanProvince,China;De-DanmentofPediatrics.SecondWestChinaHospital,SichuanUniversityChengdu6
8、10041SichuanProvince,ChinaXingkaiAn,Studyingformas?ter'sdegree,DepartmentofNeurology,WestChinaHospi?tal,SichuanUniversity,Cheng?du610041SichuanProvince.ChinaCorrespondenceto:RongPeng,Associateprofessor,Master'stutor.Depart
