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《基因組dna甲基化研究綜述》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、目錄摘要·······························································································································1Abstract·················································································································
2、········11甲基化機(jī)制··············································································································31.1動物中DNA甲基化機(jī)制··················································································31.2植物中DNA甲基化機(jī)制················
3、··································································41.3DNA甲基化與組蛋白甲基化的關(guān)系·······························································51.4甲基化DNA抑制基因轉(zhuǎn)錄沉默的機(jī)制·························································62甲基化研究技術(shù)·················
4、····················································································72.1甲基化敏感擴(kuò)增多態(tài)性·················································································82.2單分子實(shí)時(shí)測序法直接檢測DNA甲基化····················································
5、·92.3依賴于單分子納米孔技術(shù)的測序·································································93甲基化應(yīng)用···········································································································103.1DNA甲基化在植物中的應(yīng)用·····································
6、···································103.2DNA甲基化在動物中的應(yīng)用········································································104展望·······················································································································12參考
7、文獻(xiàn)···················································································································13基因組DNA甲基化研究進(jìn)展摘要：動植物基因組中存在廣泛的DNA甲基化修飾，主要存在于CpG和CpNpG位點(diǎn)。作為表觀遺傳學(xué)最重要的現(xiàn)象之一，DNA甲基化在調(diào)控自身基因表達(dá)，抵御外來入侵DNA、轉(zhuǎn)座子元件及轉(zhuǎn)基因沉默從而維持基因組穩(wěn)定等方面具有重要作用。文章主要對甲基化
8、的發(fā)生、作用機(jī)制，甲基化研究相關(guān)技術(shù)及甲基化研究應(yīng)用方面做了簡要介紹。關(guān)鍵詞：表觀遺傳；DNA；甲基化；甲基轉(zhuǎn)移酶；組蛋白AdvancesofResearchonGenomicDNAmethylationPengfeiliu(CollegeofLifeScience，GuizhouUniversity，GuiYang550025，China)Abstract：DNAmethylationiswidelyexistinplantandanimalgenom
