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1、2型糖尿病周圍神經(jīng)病變中醫(yī)證型與危險因素相關性分析作者：張廣德,鄒本良,劉蕊,黃佳娜【摘要】目的探討2型糖尿病周圍神經(jīng)病變(T2DPN)中醫(yī)證型與危險因素間的關系。方法回顧性分析112例T2DPN病例,收集其年齡、病程、體重指數(shù)(BMI)、糖化血紅蛋白(HbA1c)、收縮壓(SBP)、舒張壓(DBP)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、血肌酐(Cr)、空腹C肽(CP)、餐后2hC肽(P2hCP)等指標。遵循《糖尿病中醫(yī)防治指南》對入組病例進行辨證分型,并對上述資料進行數(shù)據(jù)分析。結(jié)果氣虛血
2、瘀證與痰瘀內(nèi)阻證相似,與陰虛血瘀證、肝腎虧虛證比較病程差異有統(tǒng)計學意義(P<0.05);氣虛血瘀證、肝腎虧虛證、痰瘀內(nèi)阻證SBP與陰虛血瘀證比較,差異均有統(tǒng)計學意義(P<0.05);HbA1c、TC和LDL-C三者相似,痰瘀內(nèi)阻證與其他3個證型間差異均有統(tǒng)計學意義(P<0.05);陰虛血瘀證Cr、CP較其他3種證型差異也有統(tǒng)計學意義(P<0.05);痰瘀內(nèi)阻證、肝腎虧虛證的P2hCP值與其他2種證型比較差異存在統(tǒng)計學意義(P<0.05)。結(jié)論按照陰虛血瘀證→氣虛血瘀證→肝腎虧虛證→痰瘀內(nèi)阻證順序,T2DPN病情有逐步加重的趨勢
3、?！娟P鍵詞】2型糖尿病周圍神經(jīng)病變;中醫(yī)證型;危險因素;相關性分析9 Abstract：ObjectiveTodiscusstherelativitybetweenriskfactorsandTCMsyndrometypesoftype2diabetesmellitusperipherialneuropathy(T2DPN).MethodsOnehundredandtwelvecasesofT2DPNinpatientswereretrospectiveanalyzed.Therelatedclinicaldatasuchasage,courseofdi
4、sease,HbA1c,SBP,DBP,TC,TG,HDL-C,LDL-C,Cr,CP,P2hCPwerecollected.TCMsyndrometypeswereclassifiedaccordingtoGuidelineforTCMDiabetesPreventionandTreatment.TherelationshipbetweenriskfactorsofT2DPNandTCMsyndrometypeswassummarizedbystatisticalanalysis.ResultsSignificantdifferenceswerefoun
5、dbetweenqideficiencywithbloodstasissyndromeandyindeficiencywithbloodstasissyndrome,andliver-kidneydepletionsyndromeinaspectofdiseasecourse(P<0.05),thesimilarresultcanbegottenwithphlegmandbloodstasisobstructingsyndrome(P<0.05).Significantdifferenceswerefoundbetweenyindeficien
6、cywithbloodstasissyndromeandothertypesinaspectofSBP(P<0.05).SignificantdifferenceswerefoundbetweenphlegmandbloodstasisobstructingsyndromeandothertypesinaspectsofHbA1c,TCandLDL(P<0.05).Significantdifferenceswerefoundbetweenyindeficiencywithbloodstasissyndromeandothertypesinas
7、pects9ofCrandCP(P<0.05).Significantdifferenceswerefoundamongliver-kidneydepletionsyndrome,phlegmandbloodstasisobstructingsyndromeandtheothertwotypesinaspectofP2hCP(P<0.05).ConclusionTherearesometrendthattheconditionofT2DPNdevelopmoreseriousdowntheorderofyindeficiencywithbloo
8、dstasissyndrome→qideficiencywithb
