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《implications of correlations between skin color and genetic ancestry for biomedical research》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、PERSPECTIVEImplicationsofcorrelationsbetweenskincolorandgeneticancestryforbiomedicalresearchEJParra1,RAKittles2&MDShriver3Skinpigmentationisacentralelementofmostdiscussionsonamongpopulationsisimportant.ToalargeextentintheUS,skinpig-‘race’andgenetics.Researchonthegeneticbasisofpopul
2、ationmentationisaproxyfor‘race’,onthebasisofwhichracismhasbeenvariationinthisphenotype,whichisimportantinmediatingbothmanifested.Skincolorcanaffectthelevelofdiscriminationapersonsocialexperiencesandenvironmentalexposures,issparse.Weexperiencesorthequalityofmedicalcareheorshereceive
3、s.Differencesstudiedtherelationshipbetweenpigmentationandancestryininskincoloramongpopulationsarecommonly(andincorrectly)http://www.nature.com/naturegeneticsfivepopulationsofmixedancestrywithawiderangeofunderstoodasanindicationofdeeperbiologicaldifferencesamongpigmentationandancest
4、ralproportions(AfricanAmericansfrompopulations.Pigmentationgenesareunlikethebulkofthegeneticvari-Washington,DC;AfricanCaribbeanslivinginEngland;Puertoationamongpopulationsandcan,andshould,beusedtohelpeducateRicansfromNewYork;MexicansfromGuerrero;andHispanicsthegeneralpublicaboutthe
5、distributionofgeneticvariationacrossthefromSanLuisValley).Thestrengthoftherelationshipbetweenpopulationsoftheworldandthelackofmeaningof‘race’asasystemofskincolorandancestrywasquitevariable,withthecorrelationsbiologicalclassification.Skinpigmentationisalsoofinterestfromtherangingini
6、ntensityfrommoderatelystrong(PuertoRico,r=biologicalpointofview.Melaninhasakeyphysiologicalrole,mediat-0.633)toweak(Mexico,r=0.212).Theseresultsdemonstrateingtheamountofultraviolet(UV)radiationreachingthedermalcapil-theutilityofancestry-informativegeneticmarkersandadmixturelariesan
7、dthereforeinfluencingtherateofUV-inducedphotolysisandmethodsandemphasizetheneedtobecautiouswhenusingphotoactivationofcompoundsthatfunctioninmanyphysiologicalpigmentationasaproxyofancestryorwhenextrapolatingthepathways.Finally,skinpigmentationisusefulasamodelphenotypeforresultsfromo
8、neadmixedpopulationtoanoth
