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1、膳食干預腸道菌群預防代謝性疾病DietaryModulationofGutMicrobiotaforPreventivemanagementofMetabolicDiseases趙立平LipingZhao上海交通大學生命科學技術學院上海系統(tǒng)生物醫(yī)學研究中心ShanghaiJiaoTongUniversityHumanSuperorganisms正確認識自己的身體－“超級生物體”諾貝爾獎得主-里德伯格,Science2000JoshuaLederbergNobelLaureate1958人體內生活著1-2公斤細菌90%在腸道里人體的細胞組成10%人細胞+90%細菌細胞人體的基因組成2
2、.5萬個人的基因3百多萬個微生物基因豐富而活躍的代謝活動腸道菌群——人體后天獲得的“第二個基因組”GutMicrobiota-Secondgenomeacquiredafterbirth食品藥品人基因組腸道微生物組健康疾病體質亞健康先天遺傳后天養(yǎng)成“慢性病的腸道起源” “人體系統(tǒng)生物學方法”慢性病的腸道起源GutOriginofChronicDiseasesIIyaMechnikovNobelLaureate1908“Laterhetookupthestudyofthefloraofthehumanintestineanddevelopedatheorythatsenilityis
3、duetopoisoningofthebodybytheproductsofcertainofthesebacteria.Topreventthemultiplicationoftheseorganismsheproposedadietcontainingmilkfermentedbybacilliwhichproducelargeamountsoflacticacidandforatimethisdietbecamewidelypopular.”-http://nobelprize.org/Symbiosisvs.Dysbiosis“糞毒入血，百病蜂起”——中醫(yī)觀念“Fecalt
4、oxinsintobloodstreamwillleadtoallkindsofdiseases”——ConceptfromTraditionalChineseMedicine(TCM)細胞毒素、遺傳毒素、免疫毒素-肝腸循環(huán)-腸屏障受損腸道菌群結構失調與代謝綜合征Cani,2009腸道菌群控制能量代謝基因表達Backhed,F.,etal.,Thegutmicrobiotaasanenvironmentalfactorthatregulatesfatstorage.ProcNatlAcadSciUSA,2004.101:15718-15723.Backhed,F.,etal.,Me
5、chanismsunderlyingtheresistancetodiet-inducedobesityingerm-freemice.ProcNatlAcadSciUSA,2007.104:979-984.Turnbaugh,P.J.,etal.,Anobesity-associatedgutmicrobiomewithincreasedcapacityforenergyharvest.Nature,2006.444(7122):p.1027-1031.Turnbaugh,P.J.,etal.,Diet-inducedobesityislinkedtomarkedbutrever
6、siblealterationsinthemousedistalgutmicrobiome.CellHostMicrobe,2008.3:213-223.JefferyGordon肥胖糖尿病炎性衰老低度、系統(tǒng)性的慢性炎癥慢性炎癥與衰老和老年病的關系InflammationandAge-relatedDiseases代謝性疾病Endotoxin-themostcommonimmunotoxin內毒素-最常見的免疫毒素內毒素MolecularInflammationinducedbyendotoxin內毒素誘導的分子炎癥Inflammationinducedbydiet-disrupt
7、edgutmicrobiota菌群結構失調誘發(fā)慢性炎癥Cani,P.D.,Amar,J.,Iglesias,M.A.,Poggi,M.,Knauf,C.,Bastelica,D.etal.(2007a)Metabolicendotoxemiainitiatesobesityandinsulinresistance.Diabetes56:1761-1772.Cani,P.D.,Neyrinck,A.M.,Fava,F.,Knauf,C.,Burcelin,R.G.,Tu
