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1、阿立哌唑替代利培酮和替代喹硫平治療精神分裂癥的療效觀察林德穎張曉東【摘要】目的：研究阿立哌唑、利培酮、喹硫平三者對精神分裂癥的療效以及不良反應(yīng)。阿立哌唑替代利培酮和替代喹硫平治療精神分裂癥的療效及安全性。方法：將123例經(jīng)利培酮治療的精神分裂癥病人換用阿立哌唑治療，將136例經(jīng)喹硫平治療的精神分裂癥病人換用阿立哌唑治療。換用阿立哌唑單獨治療精神分裂癥時間超過半年。采用簡明精神病量表（BPRS），治療中出現(xiàn)的癥狀量表（TESS）評定。監(jiān)測化驗血清催乳素（PRL）水平。結(jié)果：阿立哌唑、利培酮、喹硫平三者對精神分裂癥的療效相當(dāng)
2、，但是利培酮和喹硫平導(dǎo)致體重增加、高催乳素（PRL）血癥的副作用明顯，使病人和家屬依從性差，而阿立哌唑替代二者治療后病人的體重明顯恢復(fù)，血清催乳素（PRL）水平也恢復(fù)正常，乳腺增生、泌乳以及月經(jīng)量減少或者閉經(jīng)癥狀消失，月經(jīng)恢復(fù)正常。結(jié)論：阿立哌唑替代利培酮和替代喹硫平治療精神分裂癥的療效確切，安全性更高，完全可以取代二者治療精神分裂癥。阿立哌唑治療精神分裂癥的前景更加廣泛?！娟P(guān)鍵詞】阿立哌唑利培酮喹硫平精神分裂癥催乳素體重Objective:tostudythearipiprazole,risperdal,quetiap
3、inethreetothecurativeeffectofschizophreniaandadversereactions.Aripiprazolealternativerisperdalandalternativequetiapinetreatschizophreniasafetyandefficacy.Methods:123patientswiththerisperdaltreatmentofpatientswithschizophrenia,changewitharipiprazoletreatment,136pa
4、tientswithquetiapinetreatmentofpatientswithschizophrenia,changewitharipiprazoletreatment.Changewitharipiprazoleseparatetreatschizophreniatimemorethanhalfayear.Thebriefpsychiatricscale(BPRS),appearinthetreatmentemergentsymptomsscale(TESS).Monitoringtestsserumprola
5、ctin(PRL)level.Results:aripiprazole,risperdal,quetiapinethreetothecurativeeffectofschizophrenia,butquiterisperdalandquetiapineleadtoweightgain,highprolactin(PRL)thesideeffectsofthedisease,makeclearthepatientandfamilycompliancebad,andaripiprazolealternativetreatme
6、ntofpatientsafterbothweightmarkedly,serumprolactin(PRL)levelalsobacktonormal,mammaryglandhyperplasia,lactationandmenstrualquantitytoreduceormenopausesymptomsdisappeared,menstruationisbacktonormal.Conclusion:aripiprazolealternativerisperdalandalternativequetiapine
7、treatschizophreniasymptoms,andsafety,andcancompletelyreplacehigherbothtreatschizophrenia.Aripiprazoletreatschizophreniaandmoreextensiveprospect.【keywords】aripiprazolerisperdalquetiapineschizophreniaprolactinweightlocatedintheTomb,DongShenJiabang,deferthenextdayfo
8、cusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcame5作者單位：遼寧省
