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1、ViewPDFVersionViewPreviousArticleViewNextArticleDOI:10.1039/C0CC01738H(Communication)Chem.Commun.,2010,46,7433-7435Golfball-shapedPLGAmicroparticleswithinternalporesfabricatedbysimpleO/Wemulsion?MiRiKim?a,SeungwooLee?b,Jung-KiPark*bandKukYoungCho*aaDivisionofAdvancedMaterialsEnginee
2、ringandInstituteforRareMetals,KongjuNationalUniversity,Cheonan,Chungnam,331-717,Korea.E-mail:kycho@kongju.ac.kr;Fax:+82-41-5685776bDepartmentofChemicalandBiomolecularEngineering,KoreaAdvancedInstituteofScienceandEngineering,Daejeon,305-701,Korea.E-mail:jungpark@kaist.ac.kr;Fax:+82-4
3、2-350-3910Received4thJune2010,Accepted19thAugust2010Firstpublishedontheweb3rdSeptember2010Simpleoil-in-wateremulsionledtostructuralcomplexityatboththesurfaceandinteriorofthePLGAmicrosphere.Agolfball-likedimpledsurfacecomesfromtheheteroaggregationofvolatilenonsolventcolloidoriginatin
4、gfromtheinsideoftheorganicdropletassupportedbyinsituopticalmicroscopy.Theinternalporousstructureandencapsulationofhydrophobicagentinsidethemicroparticleimpliesitspotentialapplicationasadrugcarrier.Biodegradablepolymermicroparticleshavebeenwidelyusedassustainedreleasedepotsystemsford
5、rugs,personalcareingredients,andmedicalimagingagents.1Physicalparameterssuchasnano-/micron-scaleinternalstructures,surfacemorphology,andsizedistributionsarecritical,inthattheycanplayanimportantroleinthecontrolofloadingefficiency,releasekineticsandbiologicalactivitiesoftheencapsulate
6、dsubstances.Thus,considerableeffortsarebeingmadetopreciselycontrolthesefeatures.Inparticular,consideringthemicroparticleasacarrierforactiveagent,themainfocusisonthecontrolofinternalporestructuresofmicroparticlessuchasprovidingmicroparticleswithacontrolledhollowinteriorandporouswall.
7、2Recentlytheabilitytoimplementstructuralfeaturesonthesurfacemorphologyinthebiomedicalapplicationshasbeenatopicofintenseinterestforthepolymerfilmsurface.3Withtheconceptbeingextendedtomicroparticleswhichexhibitadimpledsurfacecombinedwithcomplexinternalporousmorphology,advantagesofincr
8、easedsurfaceareafor
