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1、《烏司他丁對膿毒癥患者腎損傷的保護作用》 [Abstract]?Objective?To?explore?the?protective?effects?of?Ulinastatin?for?the?septic?patients?with?renal?injury,?to?analyze?the?influence?on?the?prognosis?and?immune?function,?and?to?investigate?its?possible?mechanism,?and?provide?the?basis?fo
2、r?clinical?therapy.?Methods?Forty?six?patients?with?sepsis?were?selected?in?the?People's?Hospital?of?Lishui?City?from?March?2010?to?February?2014.?They?were?randomly?divided?into?the?control?group?(22?cases),?who?were?treated?with?conventional?treatment?and?nursing
3、,?and?the?observation?group?(24?cases)?were?treated?with?Ulinastatin?on?the?basis?of?conventional?therapy.?The?blood?urea?nitrogen?(BUN)?and?serum?creatinine?(SCr)?and?Cystatin?C?(Cystatin?C),?T?cell?subsets?were?evaluated,?the?serum?tumor?necrosis?factor-α?(TNF-α)
4、?and?interleukin?-6?(IL-6)?level,?and?acute?physiology?and?chronic?health?evaluation?(APACHE?Ⅱ)?scores?before?and?after?treatment?were?detected.?Results?Cystatin,?C,?BUN?and?SCr?of?two?groups?after?treatment?were?obviously?lower?than?those?before?treatment,?the?dif
5、ferences?were?statistically?significant?(P?0.05).?Cystatin?C,?BUN?and?SCr?of?the?observation?group?after?treatment?were?(1.21±0.24)?mg/L,?(14.92±1.23)?mmol/L?and?(210.74±18.36)?μmol/L,?lower?than?the?control?group?after?treatment?[(1.57±0.16)?mg/L,?(16.12±1.04)?m
6、mol/L?and?(254.33±23.82)?μmol/L]?(P?0.05).?Compared?to?before?treatment,?CD4+,?CD8+?and?CD4+/CD8+?of?two?groups,?the?differences?were?statistically?significant?(P?0.05).?CD4+?and?CD4+/CD8+?of?the?observation?group?after?treatment?was?(43.87±5.04)%?and?(1.82±0.2
7、9),?higher?than?that?of?the?control?group?after?treatment?[(38.04±4.51)%?and?(1.30±0.37)]?(P?0.05).?CD8+?of?the?observation?group?after?treatment?was?(31.92±3.26)%,?lower?than?the?control?group?after?treatment?[(35.42±3.11)%]?(P?0.05).?TNF-α?and?IL-6?of?two?gro
8、ups?after?treatment?compared?with?before?treatment,?the?difference?was?statistically?significant?(P?0.05).?TNF-α?and?IL-6?of?the?observation?gr