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1、［關(guān)鍵詞］新生兒黃疸；冷光源；藍光照射;照射時間［中圖分類號］R722.17［文獻標識碼］A［文章編號］2095-0616(2017)08-73-03［Abstract］ObjectiveToanalyzeandcomparetheefficacyofrepeatedintermittentandcontinuouscoldlightsourcebluelightirradiationinthetreatmentofneonataljaundice.Methods150casesoffull-termdelivery
2、ofnewbornswithdiseaseofjaundicewereselectedasresearchobjects.Theyweredividedintoobservationgroup(n-73)andcontrolgroup(n-77)accordingtothelightsource.Allthepatientsinthetwogroupsweretreatedwithconventionaldrugtherapyandsymptomatictreatment.Patientsincontrolgroup
3、weretreatedwithcontinuouscoldlightsourcebluelightirradiation,andpatientsinobservationgroupweretreatedwithmultipleintermittentcoldlightsource.Thelevelsofserumtotalbilirubin(TBIL)anddirectbilirubin(DBIL)weredetectedbeforeandaftertreatment,andthetherapeuticeffectw
4、asevaluatedandadversereactionswererecordedduringtreatment.ResultsTherewasnosignificantdifferencebetweenthetwogroupsinTBILandDBILbeforetreatment(P>0.05).Aftertreatment,TBIL,DBILconcentrationsofthetwogroupsweresignificantlylowerthanbeforetreatment,andtheTBIL,DBIL
5、concentrationofobservationgroupweresignificantlylowerthanthoseofcontrolgroupaftertreatment,andthedifferencewasstatisticallysignificant(P〈0.05).Theeffectiverateofthecontrolgroupwas90.9%,theeffectiverateoftheobservationgroupwas95.9%，therewasnosignificantdifferenc
6、ebetweenthetwogroups(P>0.05).Theincidenceofadversereactionsinobservationgroupwas13.7%，incontrolgroup32.5%,thedifferencewassignificantlyoftwogroups(P<0.05).ConclusionTwokindsofbluelightirradiationhavegoodclinicaleffect.Whiletheclinicalcurativeeffectissimilar,int
7、ermittentphototherapycaneffectivelyreducethebilirubinconcentrationandthechanceofadverseeventsinchildren,canandimprovetreatmentoutcomesandlifequality.Itisworthyofclinicalapplication.長時間的藍光持續(xù)照射，容易導(dǎo)致患兒煩躁不安，依從性較差，導(dǎo)致護理難度增加，患兒康復(fù)效果差，形成惡性循環(huán)［12］;且研宄顯示持續(xù)照射藍光還可能損傷新生兒染色體［1
8、3］。間歇藍光照射符合黃疸的組織分布，待深部膽紅素轉(zhuǎn)移至體表并達到一定濃度后進行光照，每次光照治療效率高，可以有效消除新生兒皮膚?表組織問隙中的問接膽紅素，達到降低體內(nèi)總膽紅素水平的目的［14-15］。本研究結(jié)果顯示，治療后兩組TBIL、DBIL濃度均較治療前顯著降低，且觀察組治療后TBIL、DBIL濃度顯著低于對照組,差異具有統(tǒng)計學(xué)意義(P
