資源描述:
《慢性腎炎采用纈沙坦聯(lián)合阿托伐他汀鈣治療的效果觀察》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、慢性腎炎采用纈沙坦聯(lián)合阿托伐他汀鈣治療的效果觀常德市第一人民醫(yī)院老年病科湖南常德415000【摘要】目的:分析慢性腎炎采用纈沙坦聯(lián)合阿托伐他汀鈣治療的效果。方法:選取106例慢性腎炎患者作為研究對(duì)象,隨機(jī)進(jìn)行分組;對(duì)照組53例,釆取纈沙坦治療;觀察組53例,在對(duì)照組治療的基礎(chǔ)上,采取阿托伐他汀鈣治療;對(duì)比兩組患者治療前后血尿素氮(BUN),血清肌酐(Scr)、超敏C-反應(yīng)蛋白(hs-CRP)、尿蛋白(PRO)、腎小球?yàn)V過(guò)率(GFR)水平,綜合評(píng)價(jià)患者的治療效果,并作對(duì)比分析。結(jié)果:治療后,兩組患者BUN、Scr、hs-CRP、PRO水平均較
2、治療前明顯降低,GFR水平較治療前明顯升高,差異具有統(tǒng)計(jì)學(xué)意義(P<0.05),但觀察組患者BUN、Scr、hs-CRP、PRO、GFR水平改善程度大于對(duì)照組,差異只有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組臨床總有效率為90.57%,大于對(duì)照組的77.36%,經(jīng)χ2檢驗(yàn),差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論:纈沙坦聯(lián)合阿托伐他汀鈣可協(xié)同提高慢性腎炎的治療效果,對(duì)于控制病情、改善腎功能及預(yù)后均只有積極作用。【關(guān)鍵詞】慢性腎炎;纈沙坦;阿托伐他汀鈣Chronicnephritisusingvalsartancombinedatorvas
3、tatincalciumtherapyEffectFuCishuangChangdeCityFirstPeople’sHospitalofGeriatrics,Changde,Hunan415000[Abstract]Objective:Toanalyzetheeffectofchronicnephritisusingvalsartancombinedatorvastatincalciumtherapy.Methods:106casesofchronicnephritispatientsasresearchsubjectswererando
4、mlygrouped;53casesinthecontrolgrouptakingvalsartantreatment;53casesofobservationgroup,onthebasisofthecontrolgrouptakingatorvastatincalciumtherapy;twocomparisonpatientsbeforeandaftertreatmentofbloodureanitrogen(BUN),serumcreatinine(Scr),high-sensitivityC-reactiveprotein(hs-
5、CRP),urinaryprotein(PRO),glomerularfiltrationrate(GFR)level,comprehensiveevaluationofpatientstreatment,andforcomparativeanalysis.Results:Aftertreatment,patientswereBUN,Scr,hs-CRP,PROlevelsignificantlylowerthanbeforetreatment,significantlyhigherGFRlevelsthanbeforetreatment,
6、thedifferencewasstatisticallysignificant^P<0.05),buttheobservationgroupwereBUN,Scr,hs-CRP,PRO,GFRlevelthedegreeofimprovementthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05);theobservationgrouptotaleffectiveratewas90.57%,77.36%higherthanthecontrolg
7、roup,theχ2test,thedifferencestatisticallysignificant(P<0.05).Conclusion:Valsartancombinedwithatorvastatincalciumsynergisticallyenhancethetherapeuticeffectofchronicnephritis,forcontrolofthediseaseandimprovekidneyfunctionandprognosisarehavingapositiveeffect.Keywords:c
8、hronicnephritis;valsartan;atorvastatincalcium慢性腎炎作為以蛋白尿、血尿、高血壓、水腫為主要臨床表現(xiàn)的免疫介導(dǎo)炎癥,病情漸進(jìn)性發(fā)展、治