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《急性百草枯中毒大鼠腎臟中細(xì)胞因子的表達(dá)及烏司他丁對(duì)其影響的研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、目錄中文摘要····························································································1英文摘要··········································································································4英文縮寫······································
2、····································································8研究論文急性百草枯中毒大鼠腎臟中炎性細(xì)胞因子的表達(dá)及烏司他丁對(duì)其影響的研究前言··········································································································9材料與方法································
3、·····························································10結(jié)果·········································································································14附圖··············································································
4、···························17附表·········································································································29討論········································································································34結(jié)論····
5、················································································39參考文獻(xiàn)·································································································40綜述百草枯中毒發(fā)病機(jī)制及治療的研究進(jìn)展·········································43致謝···
6、··············································································································54個(gè)人簡(jiǎn)歷·········································································································55急性百草枯中毒大鼠腎臟中細(xì)胞因子的表達(dá)及烏司他丁對(duì)其影響的
7、研究摘要目的：百草枯(Paraquat,PQ)，商品名稱為對(duì)草快、克蕪蹤，化學(xué)名稱為1,1’-二甲基-4,4’-聯(lián)吡啶二氯化物（1,1’-dimethyl-4,4’-dipyridylium）。它除草效果好，遇土失活，對(duì)環(huán)境不構(gòu)成污染，因此在農(nóng)業(yè)上廣泛使用，PQ中毒人數(shù)也日趨升高。自殺、誤服都可以造成中毒，一旦中毒，病情就很危重。PQ可以通過不途徑進(jìn)入機(jī)體如口服、氣道呼吸以及皮膚粘膜的接觸。當(dāng)前，雖然對(duì)PQ研究的很透徹，基本達(dá)到了分子水平，但有些具體的發(fā)病機(jī)制和途徑還不是很清楚。加之PQ無特效的治療
8、藥物，其病死率甚高，根據(jù)很多文獻(xiàn)的報(bào)道，結(jié)合已有的統(tǒng)計(jì)資料，估記在80%左右。甚高致死率引起當(dāng)前國內(nèi)外中毒專家的廣泛關(guān)注。PQ進(jìn)入機(jī)體后，主要在肺臟內(nèi)聚集導(dǎo)致肺組織結(jié)構(gòu)的損傷，但PQ要從哺乳動(dòng)物的腎臟代謝出體外，所以腎功能的好壞對(duì)于PQ中毒患者來說，極其關(guān)鍵。近年來，隨著研究的深入，推測(cè)PQ肺損傷很有可能與氧自由基引起氧化應(yīng)激反應(yīng)、炎性細(xì)胞介質(zhì)、因子的釋放、細(xì)胞凋亡及DNA損傷等有關(guān)系。本研究已經(jīng)建立了大鼠中毒模型，觀察腎組織結(jié)構(gòu)病理學(xué)的損傷，測(cè)定血漿中尿素氮(BUN
