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1、氯沙坦和辛伐他汀對(duì)糖尿病大鼠腎臟NF【摘要】目的觀察鏈脲佐菌素（STZ）誘導(dǎo)的糖尿病>P<0.05）。HE染色未見糖尿病腎病特有的結(jié)節(jié)型或彌漫型腎小球硬化表現(xiàn)，但糖尿病對(duì)照組可見明顯的腎小管上皮細(xì)胞的空泡樣變性，而正?；蛩幬镏委熃M未見相應(yīng)改變。UAER高達(dá)90μg/min以上，明顯高于正常對(duì)照組（P<0.0001）。（2）辛伐他汀和氯沙坦各自單獨(dú)治療均可使以上指標(biāo)的表達(dá)顯著抑制（與糖尿病對(duì)照比P<0.05），而且辛伐他汀的治療作用獨(dú)立于其降脂作用，但均達(dá)不到正常對(duì)照水平，兩藥聯(lián)合使用可使表達(dá)水平進(jìn)一步下降和改善。結(jié)論NF-κ
2、B、PDGF-B及PKCα的表達(dá)對(duì)糖尿病腎病起著重要的作用。氯沙坦的腎臟保護(hù)作用不同于脂類代謝的作用、氯沙坦和辛伐他汀的聯(lián)合應(yīng)用可以更好地保護(hù)腎臟，但它們真正的作用機(jī)制有待進(jìn)一步的研究。【關(guān)鍵詞】氯沙坦辛伐他汀糖尿病腎病蛋白激酶Cα血小板衍化生長(zhǎng)因子-B鏈.【Abstract】ObjectiveTheexcessiveexpressionsofTGF-β，VEGFinrenaltissueofdiabeticratshasbeenreportedrecentyears，andthechangescouldbeinhibitedechanism
3、isnotveryclear.ToresearchtheeffectsofNF-κB、PKCαandPDGF-BontheprogressionofdiabeticnephropathyandtherenoprotectivemechanismoflosartanandSimvastatinonStreptozotocin-induceddiabetic>n=8，Cgroup)，diabetescontrol(n=13，Dgroup)，diabeticratstreatedg/(kg·d)，bygavage，n=13，D1group］，dia
4、beticratstreatedvastatin［2mg/(kg·d)，bygavage，n=13，D2group］anddiabeticratstreatedvastatin［20mg/(kg·d)and2mg/(kg·d)，bygavage，n=13，D3group］.Allratsofdiabeticgroupseasuredbyimmunohistochemistry，and12-hoururinealbuminuriaexcretionrate(UAER)，plasmacholesterol，plasmatriglyceridean
5、dplasmacreatinineinedistry.ResultsAfter8eansofUAERindiabeticcontrolgroupothergroupsandorethan90μg/min.TheimmunohistochemistrystainingofNF-κB，PKCαandPDGF-Binkidneyproximaltublecytoplasmaorethanthatinglomeruler.Epithelialcellsofkidneytubleatoxylin-eosinstaining(HEstaining)byl
6、ightmicroscopy.BothlosartanandsimvastatincouldsignificantlyinhibittheexpressionsofNF-κB，PKCαandPDGF-Bindiabeticrenaltissue(P<0.05)，butcouldnotmakeitrecovery.binedtreatmentoflosartanandsimvastatincouldinhibittheexpressionsofNF-κB，PKCαandPDGF-Bfurther.Ingeneral，effectsbetv
7、astatinportantactionontheprogressionofdiabeticnephropathy.Itshouldn’tbeignoredthattheymightinjurekidneytuble.Bothlosartanandsimvastatinhavesignificanteffectondiabeticnephropathy.Therenoprotectiveeffectoflosartanisindependentuponit’seffectofregulatinglipoidmetabolism.binedtr
8、eatmentoflosartanandsimvastatincouldfurtherprotectkidneyfromdiabeticinjury.ButthEI
