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1、食管鱗癌組織COX論文逄小紅,李效良,李躍,葛兆茹,呂伯實(shí),安淑紅【關(guān)鍵詞】食管腫瘤Correlationbetphaticmetastasisinesophagealsquamouscarcinoma【Abstract】AIM:Toinvestigatethecorrelationoftheexpressionsofcyclooxygenase2(COX2)andvascularendothelialgroouscarcinomaandtheirimplicationintumorlymphaticmetastasis.METHODS:Theexpressionso
2、fCOX2andVEGFCinedbyimmunohistochemicalmethodin72casesofesophagealsquamouscarcinomaand24casesofnormalesophagealmucosa.RESULTS:ThepositiveratesofCOX2andVEGFCinesophagealsquamouscarcinomaalesophagealmucosa.TheexpressionsofCOX2andVEGFCorinvasionandlymphnodemetastasis(P0.01),butnotorsizeordi
3、fferentiation.TheexpressionofCOX2ayparticipateinVEGFClymphangiogenicpathportantroleinthelymphaticmetastasisofesophagealsquamouscarcinoma.【Keys;endothelialgrootoM,OkumuraH,etal.Prognosticfactorsinpatientsucosalesophagealcancer[J].JGastrointestSurg,2004,8(5):631-635.[2]KomatsuS,Ichikaphat
4、icvesseldensityandvascularendothelialgroalignantbehaviorinhumanpancreaticendocrinetumors[J].ClinCancerRes,2004,10(20):6919-6928.[4]JiaYT,LiZX,HeYT,etal.Expressionofvascularendothelialgrophangiogenesisandlymphaticmetastasisincolorectalcancer[J].olMed,2004,14(3):389-395.[9]FujimotoJ,Toyok
5、iH,SatoE,etal.Clinicalimplicationofexpressionofvascularendothelialgroetastaticlymphnodesofuterinecervicalcancers[J].BrJCancer,2004,91(3):466-469.[10]MurataH,Kaphaticinvasionandmetastasisinhumangastriccarcinoma[J].AmJGastroenterol,1999,94(2):451-455.[11]KyzasPA,StefanouD,AgnantisNJ,etal.
6、COX2expressioncorrelatesphnodemetastasesinpatientsouscellcarcinoma[J].ModPathol,2005,18(1):153-160.