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1、曲美他嗪聯(lián)合阿托伐他汀治療冠心病的療效及對血脂的影響【摘要】目的研究分析?R床上使用曲美他嗪聯(lián)合阿托伐他汀治療冠心病、降低血脂的效果。方法180例冠心病患者,隨機分為對照組和觀察組,各90例。對照組患者給予曲美他嗪治療,觀察組患者在對照組的基礎(chǔ)上聯(lián)合使用阿托伐他汀治療。治療后比較兩組患者的總有效率、血脂指標(biāo)以及心功能。結(jié)果①治療后,觀察組患者治療總有效率為92.2%,顯著高于對照組的82.2%,差異具有統(tǒng)計學(xué)意義(P<0.05)。②觀察組患者血清中總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)較對照組顯著降低,高密度脂蛋白膽固醇(HD
2、L-C)較對照組顯著升高,差異均具有統(tǒng)計學(xué)意義(P<0.05)。③心功能:觀察組患者左心室舒張末期內(nèi)徑(LVEDD)、左室收縮末期內(nèi)徑(LVESD)明顯低于對照組,左心室射血分?jǐn)?shù)(LVEF)明顯高于對照組,差異均具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論曲美他嗪聯(lián)合阿托伐他汀治療冠心病療效確切,優(yōu)于曲美他嗪單獨治療,具有改善患者心功能、降低血脂的雙重效果,臨床上值得廣泛推廣。中國6/vie 【關(guān)鍵詞】曲美他嗪;阿托伐他??;冠心??;降血脂 DOI:10.14163/j.ki.11-5547/r.2017.07.056 Curativeeffectbytrim
3、etazidinebinedentofcoronaryheartdiseaseanditsinfluenceonbloodlipidLUXiao-yan.ShandongDezhouCityQiheCountyPeople’sHospital,Dezhou251100,China 【Abstract】ObjectiveToresearchandanalyzeeffectbytrimetazidinebinedentofcoronaryheartdiseaseandbloodlipiddecreasing.MethodsAtotalof180patient
4、slydividedintocontrolgroupandobservationgroup,etazidinefortreatment,andtheobservationgroupreceivedadditionalatorvastatintotrimetazidineinthecontrolgroupforbinedtreatment.parisonadeontotaleffectiverate,bloodlipidindexesandcardiacfunctionbetent.Results①Aftertreatment,theobservationg
5、rouphadobviouslyhighertotaleffectiverateintreatmentas92.2%than82.2%inthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P<0.05).②Theobservationgrouphadmuchlototalcholesterol(TC),triglyceride(TG),loension(LVEDD),leftventricularendsystolicdiameter(LVESD)andhigherleftventri
6、cularejectionfraction(LVEF)thanthecontrolgroup,andtheirdifferencesallhadstatisticalsignificance(P<0.05).Conclusionbinationoftrimetazidineandatorvastatinintreatingcoronaryheartdiseaseprovidespreciselycurativeeffect,entbytrimetazidine.Thismethodshoprovingcardiacfunctionanddecreasing
7、bloodlipid,anditisotion. 【Keyetazidine;Atorvastatin;Coronaryheartdisease;Bloodlipiddecreasing