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1、基層常規(guī)治療成人急性髓細(xì)胞白血病臨床療效觀察四川省內(nèi)江市中醫(yī)醫(yī)院內(nèi)三科641000摘要目的：探究基層常規(guī)治療成人急性髓細(xì)胞白血病臨床療效。方法：選取2012年3月至2016年3月在我院治療急性髓細(xì)胞白血病患者120例，隨機均分為觀察組和對照組(各60例)，對照組采取柔紅霉素和阿糖胞昔聯(lián)合治療，觀察組采取去甲氧柔紅霉素和阿糖胞昔聯(lián)合治療，治療2個療程，比較并分析2組患者的FAB分型、治療療效、生存質(zhì)量評分、心臟毒副作用、化療不良反應(yīng)等。結(jié)果：2組患者FAB分型情況均無統(tǒng)計學(xué)差異(P>0.05)；觀察組總有效率為66.6
2、7%(40/60),對照組總有效率為58.33%(35/60),2組差異有統(tǒng)計學(xué)意義(P<0.05)；2組患者治療前牛存質(zhì)量評分無統(tǒng)計學(xué)差異(PV0.05),治療后觀察組患者的牛存質(zhì)量評分提高較對照組明顯，差異有統(tǒng)計學(xué)意義(P<0.05)o觀察組患者心臟毒副作用低于對照組，差異有統(tǒng)計學(xué)意義(PV0.05),觀察組發(fā)生其他化療不良反應(yīng)也低于對照組，差異有統(tǒng)計學(xué)意義(P<0.05)o結(jié)論：去甲氧柔紅霉素和阿糖胞昔聯(lián)合治療成人急性髓細(xì)胞白血病臨床療效更加顯著，患者牛存質(zhì)量提高明顯，值得臨床推廣。關(guān)鍵詞常規(guī)治療；柔紅霉素；去
3、甲氧柔紅霉素；阿糖胞昔；臨床療效TheClinicalobservationofprimarytreatmentofadultpatientswithacutemyeloidleukemia[Abstract]Objective:Toexploretheclinicalefficacyofprimaryconventionaltreatmentofadultacutemyeloidleukemia.Methods:120casesofacutemyeloidleukemiapatientstreatedinMarch
4、2012~2016yearinJanuaryinourhospital,wererandomlydividedintoobservationgroupandcontrolgroup(60cases),thecontrolgrouptookdaunorubicinandcytarabinecombinedtherapy,observationgrouptotakeidarubicinandcytarabinecombinedtreatment,2coursesoftreatment,comparisonandanaly
5、sisof2groupsofpatientswithFABtype,treatmentefficacy,qualityoflifescore,cardiactoxicityandadversereactionofchemotherapy?Results:2groupsofpatientswithFABclassificationshowednostatisticaldiffereneeISO(P>0.05);thetotalefficiencyofobservationgroupwas66.67%(40/60)
6、,thecontrolgrouptotaleffectiveratewas58.33%(35/60),therewassignificantdiffereneebetween2groups(P<0.05);the2groupsofpatientsbeforetreatment,qualityoflifescoresshowednosignificantdifferenee(P<0.05),observedaftertreatmentqualityoflifescoregroupsofpatientsinc
7、reasedsignificantlycomparedwiththecontrolgroup,thediffereneewasstatisticallysign訐icant(P<0.05).Theobservationgroupofpatientswithcardiacsideeffectsthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05),theobservationgrouphadotherchemotherapya
8、dversereactionislowerthanthatofthecontrolgroup,thediffereneeThereisstatisticalsign訐icance(P<0.05).Conclusion:theclinicaleffectofthecombinedtreatmentofthetreatmentofadultp
