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1、冠心病治療中口服抗血小板藥物的臨床效果研究穆棱市人民醫(yī)院黑龍江穆棱市157599【摘要】目的:研究冠心病治療中口服抗血小板藥物的臨床效果。方法:收集2013年9月-2016年9月在我院接受治療的冠心病患者54例,按照口服藥物的不同而分為兩組,一組患者28例(對照組),給予阿司匹林聯(lián)合氟毗格雷進(jìn)行治療,另一組患者26例(實(shí)驗(yàn)組),給予阿司匹林聯(lián)合普拉格雷進(jìn)行治療,對兩組患者的治療前后血小板、不良反應(yīng)以及臨床狀況的差異進(jìn)行比較。結(jié)果:在治療之前兩組患者的平均血小板聚集率(MPA)與平均血小板反應(yīng)指數(shù)(PRI)差異無統(tǒng)計(jì)學(xué)意義,即P<0.05。通過
2、對患者進(jìn)行不同藥物治療后,檢測兩組患者的PRI和MPA均有一定程度的降低,但降低幅度上實(shí)驗(yàn)組較為明顯,此外,實(shí)驗(yàn)組的患者出現(xiàn)不良反應(yīng)發(fā)牛.率為7.69%(2/26),對照組的不良反應(yīng)率為32.14%(9/28)。實(shí)驗(yàn)組的臨床事件發(fā)生率也低于對照組,通過SPSS20.0分析后,兩組患者的差異均具有統(tǒng)計(jì)學(xué)意義。結(jié)論:普拉格雷進(jìn)行冠心病的輔助治療,能有效發(fā)揮抗血小板作用,其效果優(yōu)于氟毗格雷輔助治療,所以值得在臨床上推廣使用?!娟P(guān)鍵詞】冠心病;抗血小板藥物;臨床效果Clinicalstudyoforalantiplateletdrugsinthetreat
3、mentofcoronaryheartdiseaseAbstract:Objective:Tostudytheclinicaleffectoforalantiplateletdrugsinthetreatmentofcoronaryheartdisease.Methods:Fifty-fourpatientswithcoronaryheartdiseasewhoweretreatedinourhospitalfromSeptember,2013toSeptember,2016weredividedintotwogroupsaccordingtodi
4、fferentoraldrugs.Onegroupof28patients(controlgroup)receivedAspirin,theothergrouptreatedwithaspirinandprasugrel.Thedifferencesofplateletcount,adversereactionandclinicalstatusbetweenthetwogroupswerecomparedbeforeandaftertreatment.RESULTS:Therewasnosignificantdifferenceinmeanplat
5、eletaggregationrate(MPA)andmeanplateletresponseindex(PRI)betweenthetwogroupsbeforetreatment(P<0.05).Afterthepatientsweretreatedwithdifferentdrugs,thePRIandMPAofthetwogroupsweredecreased,butthedecreaseextentwasmoreobviousintheexperimentalgroup.Inaddition,theincidenceofadvers
6、ereactionsintheexperimentalgroupwas7.69%26).Theadversereactionratewas32.14%(9/28)inthecontrolgroup.Theincidenceofclinicaleventsintheexperimentalgroupwasalsolowerthanthatinthecontrolgroup.AfterSPSS20.0analysis,thedifferencesbetweenthetwogroupswerestatisticallysignificant.Conclu
7、sion:Prasugrelisanadjuvanttherapyforcoronaryheartdisease.Itcaneffectivelyexertitsantiplateleteffect,anditseffectisbetterthanthatofadjunctivetreatmentoffluoropyridine,soitisworthytobepopularizedinclinicalpractice.Keywords:coronaryheartdisease;antiplateletdrug;clinicaleffect冠心病即
8、冠狀動(dòng)脈性心臟病,是由脂質(zhì)代謝異常而形成一些類似白色斑塊,這些斑塊累積容易而導(dǎo)致動(dòng)脈腔變狹窄,影響到正常血流,嚴(yán)重者出現(xiàn)心