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《肝動(dòng)脈化療栓塞術(shù)對(duì)原發(fā)性肝癌免疫系統(tǒng)的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫。
1、肝動(dòng)脈化療栓塞術(shù)對(duì)原發(fā)性肝癌免疫系統(tǒng)的影響摘要：目的：探討肝動(dòng)脈化療栓塞術(shù)（TACE）對(duì)原發(fā)性肝癌患者免疫系統(tǒng)的影響，了解TACE術(shù)后患者淋巴細(xì)胞變化情況。方法：選取我院2014年5月-6月份收治的原發(fā)性肝癌患者35例作為研究對(duì)象，同時(shí)選取35例健康體檢者作為對(duì)照組。術(shù)前1天、術(shù)后1周~4周分別測(cè)定患者血清中T淋巴細(xì)胞亞群和NK細(xì)胞水平，比較原發(fā)性肝癌患者術(shù)前1天淋巴細(xì)胞亞群水平和原發(fā)性肝癌患者術(shù)后1~4周淋巴細(xì)胞水平。結(jié)果：術(shù)前1d，對(duì)照組血清中CD3+、CD4+、CD4+/CD8+較原發(fā)性肝癌患者高，但CD8、CD4CD
2、25/CD4原發(fā)性肝癌患者較高；治療后1周~2周時(shí)間內(nèi)肝癌患者CD3+、CD4+、CD4+/CD8+降低，第三周開始上升，也叫術(shù)前偏高，但CD8、CD4CD25/CD4卻表現(xiàn)與之相反；NK細(xì)胞的表達(dá)與CD3+相似，差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：肝動(dòng)脈化療栓塞術(shù)術(shù)后對(duì)原發(fā)性肝癌患者的免疫系統(tǒng)有短暫的抑制作用，但在術(shù)后大約3周后免疫系統(tǒng)的功能會(huì)恢復(fù)，而且較治療前強(qiáng)。關(guān)鍵詞：肝動(dòng)脈化療栓塞術(shù)；T淋巴細(xì)胞；免疫系統(tǒng)；影響Theeffectoftranscatheterarterialchemoembolizationf
3、orprimarylivercanceroftheimmunesystemAbstract:Objective:Toinvestigatetheeffectoftranscatheterarterialchemoembolization(TACE)onimmunesysteminpatientswithprimaryhepatocellularcarcinoma,understandthechangesoflymphocytesinpatientswithTACEafteroperation.Methods:inourhos
4、pitalfrom2014-6inMayadmitted35casesofprimarylivercancerpatientsastheresearchobject,and35healthypeoplewereselectedascontrolgroup.ThepatientsweremeasuredintheserumofTlymphocytesubsetsandNKcelllevel1~4weeks1daysbeforesurgery,aftersurgery,comparedwithpatientswithprimar
5、ylivercancer1daysbeforeoperationandtheleveloflymphocytesubsetsand1~4weeksafterprimarylivercancerpatientswithlymphocytelevel.Results:thepreoperative1D,thecontrolgroupofserumCD3+,CD4+,CD4+/CD8+inpatientswithprimarylivercancer,butCD8,CD4CD25/CD4washigherinpatientswith
6、primarylivercancer;1weeksaftertreatment~2weeksCD3+,CD4+,CD4+/CD8+decreasedinpatientswithhepatocellularcarcinoma,thirdweeksbeforesurgerybegantorise,alsocalledhigh,butCD8CD4CD25/CD4,butonthecontrary;expressionofCD3+andNKcellsaresimilar,thedifferenceswerestatistically
7、significant(P<0.05).Conclusion:theinhibitoryeffectofshortonimmunesysteminpatientswithprimaryhepatocellularcarcinomaaftertranscatheterarterialchemoembolization,butafterabout3weeksaftertheimmunesystemfunctionwillrecover,butstrongerthanbeforetreatment.Keywords:hepatic
8、arterialchemoembolization;Tlymphocyte;immunesystem;effect原發(fā)性肝癌是是原發(fā)于肝臟的惡性上皮細(xì)胞腫瘤，主要包括肝細(xì)胞癌、肝內(nèi)膽管癌以及肝細(xì)胞和肝內(nèi)膽管混合癌，它是我國常見的惡性腫瘤之一[1]。由于其發(fā)病隱匿,確診時(shí)常常失去了手術(shù)治療的
