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1、第四軍醫(yī)大學(xué)博士學(xué)位論文中國(guó)HIV-1B亞型Gag、Nef、Pol和Env區(qū)保守性CTL表位的鑒定姓名：趙曙光申請(qǐng)學(xué)位級(jí)別：博士專(zhuān)業(yè)：內(nèi)科學(xué)（傳染）指導(dǎo)教師：孫永濤20070501第四軍醫(yī)大學(xué)博士學(xué)位論文縮略語(yǔ)縮略語(yǔ)英文全稱(chēng)中文全稱(chēng)aaaminoacids氨基酸獲得性免疫缺陷綜合征AIDSacquiredimmunodeficiencysyndrome（艾滋?。〢PCantigenpresentingcell抗原提呈細(xì)胞AZTzidovudin齊多夫定BSAbovineserumalbumin牛血清白蛋白bpbasepairs堿基對(duì)CIconfidenceint
2、erval可信區(qū)間CTL（Tc）cytotoxicTlymphocytes細(xì)胞毒T淋巴細(xì)胞CsAcyclosporineA環(huán)孢素ACKcytokine細(xì)胞因子DCdendriticcell樹(shù)突狀細(xì)胞DDIDideoxyinosine雙脫氧肌苷DEPCdiethylpyrocarbonate焦碳酸二乙酯dGTPdeoxyguanosinetriphosphate三磷酸脫氧鳥(niǎo)苷DMSOdimethylsulfoxide二甲基亞砜dNTPdeoxynucleosidetriphosphate脫氧核苷三磷酸D4TStavudine司他夫定EFVEfavirenz依非韋侖
3、ELISAenzymelinkedimmunosorbentassay酶聯(lián)免疫吸附試驗(yàn)EnvEnvelope膜蛋白FCMflowcytometry流式細(xì)胞儀FCSfetalcalfserum胎牛血清1第四軍醫(yī)大學(xué)博士學(xué)位論文FigFigure圖表FITCfluorescentisothiocyante異硫氰酸熒光素GagGroupspecificantigen群抗原gpglycoprotein糖蛋白gp41glycoprotein41糖蛋白gp41gp120glycoprotein120糖蛋白gp120HAARThighlyactiveantiretrovira
4、ltherapy高效抗逆轉(zhuǎn)錄病毒療法HEPESN-2’-hydroxyethylpiperazine-N羥乙基哌嗪-N’-2乙-2-ethanesulfonicacidN-2’磺酸HIV-1humanimmunodeficiencyvirustypeII型人類(lèi)免疫缺陷病毒HLAhumanleucocyteantigen人類(lèi)白細(xì)胞抗原HMAheteroduplexmobilityassay異源雙鏈泳動(dòng)分析法ICSintracellularcytokinesstaining細(xì)胞內(nèi)細(xì)胞因子染色I(xiàn)L-2interlukin-2白細(xì)胞介素-2IFN-γinterferon
5、-γγ-干擾素MHCmajorhistocompatibilitycomplex主要組織相容性復(fù)合體NefNegativefactor負(fù)因子NNRTIsnonnucleosidereversetranscriptase非核苷類(lèi)逆轉(zhuǎn)錄酶抑制NRTIsnucleosidereversetranscriptase核苷類(lèi)逆轉(zhuǎn)錄酶抑制inhibitors劑NVPNevirapine奈韋拉平PCRPolymeraseChainReaction聚合酶鏈?zhǔn)椒磻?yīng)PolymerasechainreactionwithsequencePCR-SSP系列特異性引物PCR-specifi
6、cprimersPBMCperipheralbloodmononuclearcell外周血單個(gè)核細(xì)胞PBSphosphate-bufferedsaline磷酸鹽緩沖液PolPolymerase多聚酶RevRegulatorofexpressionofviralproteins病毒蛋白表達(dá)調(diào)節(jié)因子2第四軍醫(yī)大學(xué)博士學(xué)位論文RNARibonucleicAcid核糖核酸RNaseribonucleaseRNA酶RT-PCRReverseTranscriptasePCR反轉(zhuǎn)錄PCRSFCspotformingcellsIFN-γ分泌細(xì)胞數(shù)SIVsimianimmunod
7、eficiencyvirus猿猴免疫缺陷病毒STIStructuredtreatmentinterruption策略性暫停療法TabTable表TatTransactivitor反式作用因子TD-PCRTouchdownPolymeraseChainReaction降落PCRThThelpercell輔助T細(xì)胞TCRTcellreceptorT細(xì)胞受體TNF-αtumornecrosisfactor-α腫瘤壞死因子-αμlmicroliter微升VifVirioninfectivityfactor病毒感染因子VprViralproteinRR蛋白VpuViral
8、proteinUU蛋白3
