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1、貴陽中醫(yī)學(xué)院碩士學(xué)位論文賦形性、初黏力等進(jìn)行了考察和測(cè)試。結(jié)果表明，薄層鑒別分離度良好，專屬性強(qiáng)。含膏量、賦形性和初黏力符合《中國藥典》(2010年版一部)要求。采用HPLC法對(duì)三七總皂苷凝膠膏劑中的三七皂苷Rl、人參皂苷RgI、人參皂苷Rbl三種成分進(jìn)行測(cè)定，結(jié)果顯示三七總皂苷凝膠膏劑中三種成分的含量穩(wěn)定，其含量分別為三七皂苷RI1．68mg·百1，人參皂苷Rgl14．6mg·百1，人參皂苷Rbl3．30rag·百1。6．三七總皂苷凝膠膏劑的穩(wěn)定性研究：為了研究三七總皂苷凝膠膏劑的穩(wěn)定性，進(jìn)行了3個(gè)月的常溫留樣觀察和加
2、速穩(wěn)定性實(shí)驗(yàn)研究，結(jié)果表明三七總皂苷凝膠膏劑的感官評(píng)價(jià)、初黏力、含藥量均穩(wěn)定，說明三七總皂苷凝膠膏劑3個(gè)月穩(wěn)定性良好。關(guān)鍵詞：三七總皂苷；凝膠膏劑；體外滲透性；質(zhì)量標(biāo)準(zhǔn)2貴陽中醫(yī)學(xué)院碩士學(xué)位論文ResearchonPNSCataplasmAbstractInordertodevelopanewlytransdermaldeliverysystemandpromotthedevelopmentofChinesemedicine，IdidasystematicstudyofPNScataplasmpreparation,co
3、ntentdetermination,invitropermeation,safety,qualitystandardsandstability．Theresearchmainlyincludesthefollowingaspects：1．PreparationofPNScataplasm：Inordertoprepareanappropriateblankbase，adhesionandphysicalpropertiesaleusedasevaluationindexes，andtheamountsofbasemat
4、erialsareusedasinvestigationfactors．Throughthepreliminarytest,singlefactoretestandtheorthogonaltestmetho也theoptimalblankbaseprescriptiOilofPNScataplasmisNP一700---CMC-Na(4：1)59，Kaolin3．59，Dihydroxyalumimunaminoacetate0．189，Glycerol--Propanediol(2：1)259，PVP—K900．59
5、，PVPP0．59，PVA0．259．Withthisoptimalprescriptionbetterqualitycataplasmcanbeprepared．2．ContentdeterminationofPNScataplasm：TodeterminingthecontentofPNScataplasm，usingHPLCtodeterminethecontentsofnotoginsenosideRI，ginsenosideRgl，ginsenosidRbl．Resultsshowedthatthismetho
6、dissimpleandreliable．ThecomponentisnotoginsenosideRl1．68mg·g-1，ginsenosideRgl14．60mg·g-1，ginsenosidRbi3．30mg·g～．3．TheinvitropermeationofPNScataplasm：ThepermeationexperimentsweretostudytheinvitropermeationofPNScataplasm．Determiningthepermeationamountofnotoginsenos
7、ideRl，giusenosideRglandginsenosidRbiWasbyHPLC．TheoptimizingpermeationmediumWasnitrocellulosemembraneandpermeationenhancerWasAzone．The24haccumulativepermeationamountofPNScataplasmWas683．968I_tg·cm-2．TheiIlvitropermeationCallbedescribedbymodelofHiguchiequation，andp
8、ermeationrateWas17．803p,g·cm-2．min～．4．MedicationSafetyStudyofPNScataplasm：3貴陽中醫(yī)學(xué)院碩士學(xué)位論文Inordertoensurethesafetyofdruguse，thisstudywastosurveyacutedermalirritat
