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1、1lI目錄帥IllLIlIIIIIIIIIlUlIIIlllllllIIIilllltllY1801615中文摘要???????????????????????··1英文摘要DOO??????????????OOO?????··5英文縮寫··OOO?·OOO??????????OOo???··10研究論文硫化氫對(duì)大鼠急性心肌缺血的影響引言O(shè)ODOO······················．．．．．．．．．．．．．·················．·．．·．．．11第一部分急性心肌缺血大鼠內(nèi)源性硫化氫／胱
2、硫醚一Y一裂解酶體系的變化前言····························．··．．．．．．．．．．．．．··．······．．．．．．．?．．．．．．．12刖舌····························································?·······12材料與方法????????????????????．．12結(jié)果·OOO················································．．．．．．．15附圖······
3、··································．··．-·········-·····．．．．．．．．．．16附表·······························································．．．．．．．22討論······································．．．．．．···············．．．??．．24／J、結(jié)····”·······“···········一···．．·．·??．．·??·?·
4、··．．．．一．．．．．．25參考文獻(xiàn)?????????????????????．25第二部分硫化氫對(duì)心肌缺血大鼠線粒體功能及細(xì)胞凋亡的影響前言．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．7．．．．．．．．．．．．．．．．．．．．．．．．27日IJ舌·-···········································?························2’7材料與方法????????????????????．-27結(jié)果·····
5、·······?·-·?················．··．·．．··························32附圖····················OOO····································．．·····．．．34附表······························．·．．．．．．．．．．．．．··．．．．．．．．．．．．．．．．．．．．．．．42討論·-·················?．．．．．．．．．．．．．．．．．．．．．．．·．
6、．．．．．．．．．．．．．．．．．．．．．．．45／J、結(jié)·一·”···”··”·····一一··一·一一．．．．．．．．．一”””．”””“．．．．．．．．．．．47參考文獻(xiàn)??·???????????????????．47結(jié)論·····································．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．49綜述內(nèi)源性硫化氫與心血管疾病的研究進(jìn)展????????．．50致謂十··-····························
7、·············．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．61個(gè)人簡歷???????????????????????．62中文摘要硫化氫對(duì)大鼠急性心肌缺血的影響摘要心肌缺血是指心臟的血液灌注減少，導(dǎo)致心臟的供氧減少，心肌能量代謝不正常，不能支持心臟正常工作的一種病理狀態(tài)，嚴(yán)重威脅人類的身心健康，因而對(duì)于缺血心肌保護(hù)的研究是倍受關(guān)注的課題。大量動(dòng)物實(shí)驗(yàn)及臨床試驗(yàn)均表明，細(xì)胞凋亡是急性心肌缺血損傷發(fā)病機(jī)制的重要環(huán)節(jié)之一，線粒體在細(xì)胞整合各種凋亡刺激信號(hào)的過程中處于樞紐地位。作為繼一氧
8、化氮(nitricoxide，NO)和一氧化碳(carbonmonoxide，co)之后的第三種重要化學(xué)遞質(zhì)和細(xì)胞內(nèi)信號(hào)分子一硫化氫(hydrogensulfide，H2S)一直倍受醫(yī)學(xué)界的關(guān)注。內(nèi)源性H2S主要由半胱氨酸等含硫氨基酸在胱硫醚．13．合成酶(cystathionine．p．synthase，CBS)和胱硫醚．y．裂解酶(cystathionine-丫．1yase，CSE)作用下生成的
