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1、摘要定性差和鍵和型纖維素類CSP手性拆分性能差的缺點。關(guān)鍵詞：離子液體B一環(huán)糊精纖維素手性固定相手性拆分ⅡAbstractIonicliquidbecauseofitsuniquenaturehasawiderangeofapplicationsontheseparationandpurification．Cyclodextrinandcelluloseisopticallyactivenaturalpolymer，andischeapandeasytoget．Ashighpressureliquidchromatography(HPLC)
2、chiralstationaryphase(CSP)，theyhavehighselectivityandawiderangeofapplications．Thepurposeofthisstudyistoexplorethesynergiesgeneratedbycombiningtheionicliquidandchiralactivemoleculesbothimmobilizedonthesurfaceofsilicagelandresearchapplicationperformanceonchiralseparationandp
3、urificationoffinechemicalsfield．Themaincontentsandresultsarcasfollows：1．Adoptingbatchfeeding，6-deoxy—tosyl-p—Cyclodextrin(6-OTs—p-CD)ispreparedbythereactionof13-Cyclodextrin(13一CD)andp-toluenesulfonylchloride(p—TsCl)insodiumhydroxideaqueoussolution．Bysingle-factormethodexa
4、miningeffectofreactionconditionontheyield，theoptimumtechnologicalconditionsarefoundasfollows：totalreactiontime5h，reactiontemperature0℃，alkalisolubility0．45mol／L，theamountofalkalisolution240mL(whentheamountof13-CDis8g)，咒(p—TsCl)：n(13-CD)=4．Undertheseconditions，theyieldof6-O
5、Ts—p—CDisupto46．2％．Thenbymulti—stepreaction．the13-cyclodextrinchiralionicliquidwithcertainchairalseparationperformanceandthermalstabilityisprepared．TheproductsofeachstepofthereactionarecharacterizedbyinfraredspectroscopyandNMRtodeterminethestructure．2．Bythepolymericgraftin
6、gmethod，the[3-cyclodextrinchiralionicliquidisimmobilizedtothesurfaceofthesilicagel，obtainingchiralstationaryphaseCSPI．Testingchiralseparationperformance，theresultsshowthat：1)CSPIdoesnotfitinthenormalphasemode，becauseitispronetoswelling，resultingincolumnpressureincreasing．2
7、)Undertheinvertingmode，CSPIseparatesavarietyofacidicchiralcompoundenantiomers，andhasgoodstability，buthaspoorseparationperformanceforalkalineandneutralchiralcompounds．TakingDL—alpha—Methoxyphenylaceticacidforexample，theeffectofthemobilephaseconditionsonseparationIIIAbstract
8、performanceshowsthat：whenthemethanol／water=30／70(V／功，theseparationdegreeislarger；flowrate
