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1、摘要IIIHIIIIIIIIIIIIIIIIIIIIiqllIIlY2427194目的:肝癌合并非重度門脈高壓患者治療的原則尚無統(tǒng)一定論,進(jìn)一步研究非重度門脈高壓對肝癌患者行手術(shù)切除的預(yù)后影響,探討對肝癌合并非重度門靜脈高壓癥患者行單純肝癌切除的療效以及手術(shù)治療可行性、適應(yīng)證和圍手術(shù)期注意事項(xiàng),為該類患者選擇適當(dāng)?shù)闹委煼椒ㄌ峁┡R床依據(jù)。方法:回顧性分析182例肝癌并肝硬化接受手術(shù)切除治療的患者的臨床資料,根據(jù)有無門脈高壓癥將其分為門脈高壓組(n=91)、非門脈高壓組(n=91),比較兩組患者術(shù)后的預(yù)后情況。結(jié)果:分析兩組患
2、者術(shù)前資料,門脈高壓組較非門脈高壓組有較低的白蛋白水平、較長的凝血時(shí)間、較高的總膽紅素水平、較小的腫瘤直徑;術(shù)后比較,門脈高壓組有較高的肝功能相關(guān)性術(shù)后并發(fā)癥(26.37%VS8.79%P=O.002);然而兩組術(shù)后肝衰竭發(fā)生概率(6.59%VS2.20%P=O.278),術(shù)后上消化道出血概率(3.3%VSO%P=O.246),3年、5年總體生存率差異無統(tǒng)計(jì)學(xué)意義(56.3%VS56.8%P=0.832;31.5%VS32.7%P=0.919);多因素分析腫瘤直徑大于10cm、脈管侵犯、術(shù)前AFP>400ng/ml是獨(dú)立的
3、預(yù)后因素。結(jié)論:非重度門脈高壓癥患者接受單純的肝癌切除與肝癌非門脈高壓患者肝癌術(shù)后肝功能衰竭發(fā)生率、術(shù)后上消化道出血率、3年及5年總體生存率差異無統(tǒng)計(jì)學(xué)意義,非重度門脈高壓患者接受單純肝癌治療亦可獲得良好的預(yù)后。關(guān)鍵詞:肝細(xì)胞肝癌;非重度門脈高壓癥;預(yù)后影響;手術(shù)切除AbstractABSTRACTAim:Inchina.thebesttherapeuticschedulefornon—seriousPortalhypertensionpatientswithHepatocellularcarcinoma(HCC)isst
4、illfarfrombeingestablished,tofutureclarifythepost.operativeprognosticrelevanceofnon-seriousPortalhypertensionincirrhoticpatientswithHCC,toStudyofhepaticresectionoperationtreatmentefficacy,feasibili垓indicationsandoperationperiodnoteinthosepatients,inordertoselectth
5、emostsuitablemethodforthesepatients.Methods:Atotalof182cirrhoticpatientswhounderwentcurativeresectionofHCCwereeligibleforthisanalysis.Patientsweredividedintotwogroups:PHTgroup(n=91)andnon-PHTgroup(n291).Theshort。andlong。termoutcomesofthesepatientswereanalysedretro
6、spectively.Result:PatientswithportalhypertensionhadworsepreoperativeAlbumin,longerProthrombinTime,higherTotalbilirubin,andsmallertumorsize.PatientswithportalhypertensionhadhigherLiver—relatedmorbidity(26.37%VS8.79%P=0.002),butoperative1iverfailure(6.59%VS2.20%P=0.
7、278),operativeuppergastrointestinalhemorrhage(3.3%VSO%P=0.246),也e3-year,5-yearoverallsurvivalratewassimilarf56.3%VS56.8%P=0.832;31.5%VS32.7%P=0.919).Multivariateanalysisidentifiedthattumordiameter>10cm,vascularinvasionandAFP>400n∥mlwereasindependentpredictingfacto
8、rsforsurvival.Conlelusion:Short.a(chǎn)ndlong。termoutcomesofhepaticresectioninHCCpatientswithandwithoutPortalhypertensionalesimilar,non-seriousPHTpatientswith