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《降逆解郁湯治療肝胃不和型膽汁反流性胃炎的臨床研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、提要目的：觀察降逆解郁湯治療膽汁反流性胃炎（Bilerefluxgastritis，BRG)，中醫(yī)辨證為肝胃不和型的臨床療效，并且從理論和臨床研究?jī)蓚€(gè)方面探討降逆解郁湯治療肝胃不和型BRG的機(jī)制。方法：臨床選擇符合納入標(biāo)準(zhǔn)的BRG患者60例，隨機(jī)分為兩組，實(shí)驗(yàn)組（30例）給予降逆解郁湯，對(duì)照組（30例）給予枸櫞酸莫沙必利分散片和雷貝拉唑鈉腸溶片，兩組均以4周為一療程。觀察兩組的臨床療效，并對(duì)治愈患者隨訪6個(gè)月，觀察遠(yuǎn)期療效。結(jié)果：臨床研究顯示，實(shí)驗(yàn)組中醫(yī)證候療效、胃鏡療效及遠(yuǎn)期抗復(fù)發(fā)療效等均優(yōu)于對(duì)照組（P＜0.05或P＜0.01）。實(shí)驗(yàn)組能明
2、顯改善胃脘脹滿或疼痛，嘈雜不適，吞酸、噯氣、惡心、口苦、不欲食、情緒抑郁、善太息等癥狀，其療效優(yōu)于對(duì)照組（P＜0.05或P＜0.01）。兩組治療期間均未發(fā)生不良反應(yīng)。結(jié)論：降逆解郁湯是治療肝胃不和型BRG的有效方劑，其機(jī)理可能與促胃腸動(dòng)力、抑酸、改善黏膜血流量、增強(qiáng)黏膜屏障、抗炎等有關(guān)，經(jīng)大量臨床資料調(diào)查，無(wú)明顯不良反應(yīng)，值得進(jìn)一步推廣應(yīng)用。關(guān)鍵詞降逆解郁湯；膽汁反流性胃炎(Bilerefluxgastritis，BRG)；肝胃不和；臨床研究ClinicalStudyofTreatingBilerefluxgastritisofsyndrom
3、eofincoordinationbetweenliverandstomachwithJiang-ni-jie-yu-tangSpecialty：GastroenterologyInternalMedicineofTCM.Author：ZhangChunlanTutor：ProfessorLuGuangchaoAbstractObjective:ToobservetheeffectofJiangnijieyutang(JNJYT)onBilerefluxgastritis(BRG)，andexplorethemechanismofit.Met
4、hods:60patientswithBRGweredividedintotwogroupsatrandom:thetreatmentgroupandthecontrolgroup.ThetreatmentonewasgivenJNJYT，andthecontrolonewasgivenMosaprideCitrateDispersibleTabletsandRayBellaofintestinalsodiumtablets.Fourweeksweresetasacourseoftreatment.Theclinicaleffectsofea
5、chgroupwereobservedduringthecourseandthefollow-upsurveyof6months.Results:TheeffectiveofsyndromeofTCM、enteroscopyobservingofthetreatmentgrouparesuperiortothatofthecontrolgroup(P＜0.01orP＜0.05).JNJYTcanobviouslyimprovethesymptomssuchasStomachburningpaindiscomfortordullpain，noi
6、sy，fullness、mouthpain、anorexia、nausea、irritablemoodetc.thanMosaprideCitrateDispersibleTabletsandRayBellaofintestinalsodiumtablets(P＜0.01orP＜0.05).Conclusions:JNJYTisinforceinthetreatmentofBRG.Themechanismofthistherapymaybeimmediatelyinvolvedinpromotinggastrointestinalmotili
7、ty、acidsuppression、toimprovemucosalbloodflow、toenhancethemucosalbarrier,anti-inflammatoryetc.Keywords：Jiang-ni-jie-yu-tang(JNJYT)；Bilerefluxgastritis(BRG)；syndromeofincoordinationbetweenliverandstomach；Clinicalstudy.目錄引言......................................................
8、.........................................................................1臨床研究....
