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1、提要目的:本研究采用隔藥灸臍法治療原發(fā)性痛經(jīng),以健康受試者為對照,觀察治療前后血漿及尿液的代謝產(chǎn)物譜,找出潛在的生物標記物,推導(dǎo)相關(guān)代謝通路,借此探明隔藥灸臍法治療原發(fā)性痛經(jīng)效應(yīng)機理所在。方法:選取原發(fā)性痛經(jīng)患者10例,正常對照組10例,通過檢測患者血液、尿液等的代謝產(chǎn)物譜,尋找其潛在的生物標記物,推導(dǎo)相關(guān)代謝通路。結(jié)果:隔藥灸臍法治療原發(fā)性痛經(jīng)的代謝產(chǎn)物譜發(fā)生了顯著變化,其主要表現(xiàn)為:皮質(zhì)酮、羥脯氨酸、亮氨酸、脫氧皮質(zhì)酮及苯甲酸、二氫神經(jīng)鞘氨醇,這些代謝物涉及到體內(nèi)類固醇激素、一氧化氮、神經(jīng)遞質(zhì)代謝及氨基酸代謝等過程。結(jié)論:隔藥灸臍法治療原發(fā)性痛經(jīng)的代謝
2、組學(xué)機制主要是通過調(diào)整原發(fā)性痛經(jīng)患者異常的生殖內(nèi)分泌激素水平,改善其神經(jīng)、免疫、內(nèi)分泌網(wǎng)絡(luò)狀況,從而減輕痛經(jīng)的疼痛程度并改善其伴隨癥狀。關(guān)鍵詞隔藥灸臍法;原發(fā)性痛經(jīng);代謝組學(xué)TheStudyofMetabonomicsofUmbilicalMoxibustionwithHerbalMedicineonPrimaryDysmenorrhealSyndromeSpeciality:Acupuncture,MoxibustionandMassageAuthor:YuXiaojingTutor:GaoShuzhongAbstractObjective:Bydete
3、ctingmetabolicspectrumofpatients`bloodandurea,tofindoutpotentialbiologicalmarkerandtrytoderiverelatedmetabolicpathwayofumbilicalmoxibustiononprimarydysmenorrhealsyndrome,andtotrytofindoutthemechanismofumbilicalmoxibustiononprimarydysmenorrhealsyndrome.Methods:10primarydysmenorrhea
4、lpatientswererandomlyselectedintreatinggroupand10healthyfemaleincontrolgroup.Bydetectingmetabolicspectrumofpatients`bloodandurea,tofindoutpotentialbiologicalmarkeranddeducerelatedmetabolicpathwayofumbilicalmoxibustiononprimarydysmenorrhealsyndrome.Results:Themetabolismspectrumofpa
5、tientswithprimarydysmenorrhealsyndromehadsignificantlychanged.Thesubstanceschangedwerecorticosterone,hydroxyproline,LeucineandDeoxycorticosterone,2-Methylbenzylbenzoate,Pidolicacid,Ethylhomovanillate,p-Coumaricacid,andPiperidineandSphinganine.ThesemetabolitesinvolvedSteroidhormone
6、biosynthesis,nitricoxide,neurotransmittersmetabolism,andaminoacidmetabolismprocess.Conclusion:Themetabolicmechanismsofumbilicalmoxibustiononprimary,dysmenorrhealsyndromearetoadjustpatientswithprimarydysmenorrheaabnormalreproductiveendocrinehormonelevel,toimprovetheirnervous,immune
7、,endocrinenetworkstatustoreducepainandtoimproveconcomitantsymptomsofprimarydymenorrhea.Keywordsumbilicalmoxibustionwithherbalmedicine;primarydysmenorrhea;metabonomics目錄引言...............................................................................................................
8、................1資料與方法...........