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1、萬方數(shù)據(jù)英文摘要TheValueofCombinedDetectionofMultipleIndicesforDiagnosisofCultureNegativeTuberculosisABSTRACTTuberculosis，amajorinfectiousdiseasewhichendangersoverallhumanity,iSacrucialissueofpublichealthandseriOUSsocialproblem．China，followingIndia，confirmedthesecondlargestTB?infectedpopulationinthewor
2、ld．TuberculosisiSachronicinfectiousdiseasecausedbyMycobacteriumtuberculosis，withrespiratorydropletsastheprinciplemediaoftransmission．BacteriologicalexaminationofTBisamajormeansofidentifyingthesourcesofTBinfection．a(chǎn)swellastheimportantbasisforTBconfirmationandchemotherapyregimens．Culturenegativet
3、uberculosis，accountingforabout40％．60％ofalltheTBdiagnosis，iSclassifiedasanactiveTBwithnegativetypebasedontherespectivedetectionsofsputummycobacteriumandsputumsmearacidfastbacilli．Duetothehiddensymptomsofculturenegativetuberculosis，somepatiemsmayconverttosmear-一poSltlVepulmonarytuberculosis，ifthe
4、yfailtogettimelydiagnosisandtreatment。Thekeytotheeffectivediagnosisandtreatmentoftuberculosisisearlydiscovery,earlydiagnosis，andearlytreatmentwithearlydiagnosisonthetop．Nowadays，therearemultiplemethodsofTBdiagnosis：thechestimagingdetection，bacteriologyinspection，immunologicaldiagnosis，cytokines
5、detection，moleculardiagnosis，andetc．a(chǎn)sthecommonelinicalpractices．Buteachofthesemethodshascertainlimitations，resultinginthefailureoftimelyandpromptdiagnosisofculturenegativetuberculosis．Culturenegativetuberculosisisalwayssubjectedtomisdiagnosisormisseddiagnosisduetothelackofconclusiveevidenceofb
6、acteriologicalexamination，merelybasedonsuchgeneralanalysisasmedcNhistory,symptoms，chestX-ray,chestCT，laboratoryexamination，andetc．Therefore，thediagnosisofculturenegativetuberculosisundergoesconsiderabledimculties．Withthedevelopmentoflaboratoryexaminationtechnology,thediscoveryandapplicationofva
7、rious萬方數(shù)據(jù)英文摘要diagnosticmethodscarlimprovetheearlydiagnosisofculturenegativetuberculosisObjective：ToinvestigatethevalueofdeterminationofDNAfromMycobacteriumtuberculosis(TB．DNA)obtainedfromthesputumorbronchoalveolarlavagefluidsubjec
