急性冠脈綜合征中炎性細(xì)胞因子與基質(zhì)金屬蛋白酶的關(guān)系研究

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時(shí)間:2019-02-27

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1、碩士學(xué)位論文Thestudyofthecorrelationsbetweeninflammatorycytokinesandmatrixmetallo--proteinasesinacutecoronarysyndromeName:UUSupervisor:ZHANGQingHuaPartOneChangesoftheseruminflammatorycytokinesandPregnancy。associatedPlasmaProtein-Alevelsinthepatientswithacutecoronarysyndromeandtheirclinicalcorrelations

2、Background:Acutecoronarysyndrome(ACS)isincludingaseriesofclinicemergencycasesfrominstabilityanginapcctofistocardiacdeath,andits’clinicalmanifestationoccurrencesuddenlyandseriously.Recently,aftermassiveinvestigations,peoplehaveknownthatthekeypointofthedevelopmentofACSwasnotthenarrowdegreeofthecor

3、onaryartery,buttheerosionordisruptionofthevulnerableplaquesandthesubsequentthrombogenesis.Abroadstudiesindicatethatmostofthecriminalplaquesinthepatientswhodiedofacutemyocardialinfarction(AMI)werevulnerableplaques,andsubsequentresearcheshavefoundthatinflammationplayanimportantroleinit.Thereareman

4、ymacrophages,monocytesinABSTRACTthevulnerableplaques,andtheycallsecreteinflammatoryfactors,likeinterleukin-113(1L-1B),interleukin-6(IL-6)andtumornecrosisfactorandSOon.LotsofinvestigationsindicatedthattherewereSOmecorrectionsbetweenaseriesofplasmaactivematerialsofplaquedestabilizationandinflammat

5、ion.Pregnancyassociatedplasmaprotein-A(PAPP—A),abrandnewinflammationbiomakerwhichCallrecognizeandpredicttheplaque,becomethehotspot.PAPP-AisamemberofmatrixmetalloproteinasesfamilywhichcantakepartintheprogressofACSthroughmanyways.Inthispart,weinvestigatethechangesofserumIL-1B,IL-6andPAPP-Alevelsin

6、thepatientsofdifferenttypesofcoronaryarterydiseases,andanalysistherelevanciesbetweenthemWehopethatitcanindicatetheclinicalassociationsbetweeninflammatorycytokinesandPAPP-Aandcananalyzetheeffectofi.001_mationinthedevelopmentofACS.Objectives:ToinvestigatechangesofserumIL-1B,ID6andPAPP—Alevelsinthe

7、patientsofdifferenttypesincoronaryarterydisease,discusstherelevanciesbetweenthem,andanalysistheirclinicalrelevancieswithage,bodymassindex(BMI),glucose(GLU),totalcholesterol(TC),triglyceride(TG),lowdensitylipoprotein(LDL)andh

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