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1、分類號學號M201175103學校代碼10487密級碩士學位論文小膠質細胞HMGB1-TLR4信號通路在大鼠可卡因成癮中的作用及機制學位申請人：張培煒學科專業(yè)：藥理學指導教師：陳建國教授答辯日期：2013年12月萬方數(shù)據(jù)ADissertationSubmittedforMasterDegreeinMedicineEffectsandmechanismsofhighmobilitygroupBox-1-Toll-like4receptorsignalingpathwayinmicrogliaofcocaine-addictedratsCand
2、idate:ZhangPei-WeiMajor:PharmacologySupervisor:Prof.ChenJian-GuoDepartmentofPharmacology,TongjiMedicalCollegeHuazhongUniversityofScience&TechnologyWuhan,HubeiProvince430030,P.R.ChinaDecember,2013萬方數(shù)據(jù)華中科技大學碩士學位論文獨創(chuàng)性聲明本人聲明所呈交的學位論文是我個人在導師指導下進行的研究工作及取得的研究成果。盡我所知，除文中已經標明引用的內容外，
3、本論文不包含任何其他個人或集體已經發(fā)表或撰寫過的研究成果。對本文的研究做出貢獻的個人和集體，均已在文中以明確方式標明。本人完全意識到本聲明的法律結果由本人承擔。學位論文作者簽名：日期：年月日學位論文版權使用授權書本學位論文作者完全了解學校有關保留、使用學位論文的規(guī)定，即：學校有權保留并向國家有關部門或機構送交論文的復印件和電子版，允許論文被查閱和借閱。本人授權華中科技大學可以將本學位論文的全部或部分內容編入有關數(shù)據(jù)庫進行檢索，可以采用影印、縮印或掃描等復制手段保存和匯編本學位論文。保密□，在_____年解密后適用本授權書。本論文屬于不保密□
4、。（請在以上方框內打“√”）學位論文作者簽名：指導教師簽名：萬方數(shù)據(jù)華中科技大學碩士學位論文目錄縮略詞表························································································1中文摘要························································································2ABSTRACT·······························
5、····················································5前言···························································································8第一部分小膠質細胞HMGB1/TLR4信號通路在大鼠可卡因成癮中的作用12材料和方法················································································12結果
6、·························································································15討論·························································································28小結·······················································································
7、··30第二部分抑制小膠質細胞活性對可卡因誘導大鼠成癮行為的作用及機制···32材料和方法···············································································32結果·························································································35討論····················································
8、·····································43小結················································
