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1、中國超聲醫(yī)學雜志2012年3月第28卷第3期ChineseJItrnd超聲造影在HIFU治療原發(fā)性肝癌療效評價中的應用價值張學蘭楊潔摘要目的通過超聲造影對HIFU治療原發(fā)性肝癌(HCC)的觀察,了解超聲造影對HIFU療效的評價作用,并進一步指導HIFU的治療。方法68例肝癌患者(89個病灶)隨機分為A、B兩組,其中A組41例(55個病灶)治療前及治療后10rain進行超聲造影檢查,觀察腫瘤組織血供情況,了解腫瘤組織內部有無殘留血供和遺漏病灶,并對未完全滅活的病灶針對性地進行HIFU補充治療;B組27例(34個病灶)為對照組。觀察治療的安全性及治療前后臨床癥狀、肝功能、
2、AFP等各項指標的變化。結果HIFU治療后行超聲造影發(fā)現(xiàn)A組24個病灶未完全滅活并進行補充治療。全部患者均無嚴重并發(fā)癥出現(xiàn),治療后A、B兩組患者甲胎蛋白值下降率分別為83.3%、59.7;半年、1年、2年生存率分別為100、89.7、85.3和85.2、75.0%、61.5;兩組差別均具有統(tǒng)計學(P
3、sonOgraphyforEvaluatingtheCurativeEffectofHIFUforHepatoceIlularCarcinomaZhangXuelan,YangJieDepartmentofUltrasound,PeopldsHospitalofGansuProvince,Lanzhou,Gansu730000ChinaAbstract:0bjectiveTodeterminethevalueofcontrast—enhancedu1trasonography(CEUS)forevaluatingthecurativeeffectofHIFUonpri
4、maryHCCtofurtherguidetheperformanceofHIFU.MethodsSix-eightcases(89le—sion)ofhepatocellularcarcinoma(HCC)wererandomizedinto2groups,41cases(55lesion)ingroupAand27cases(34lesion)ingroupB.PatientsofgroupAwereexaminedbycontrast—enhancedultrasoundbeforeandaftertherapyin10minutes.Thelesionofin
5、completedeactivationweretreatedbyHIFUintime.Thetreatmentsecurityandthether—apeutieeffectswereobservedbytheclinicalsymptom,serumAFPandcontrast—enhancedultrasoundappearance.Thelong—termtherapeuticeffectswerejudgedbyfollow-upsurvivalrate.Results24lesioningroupAwerefoundincom—pletedeactivat
6、ionandrunsupplementarytreatmentintime.Noseriouscomplicationwasidentified.TheAFPdescend—ingratewas83.3ingroupA,59.70.4ingroupB,respectively(P<0.05).Sixmonths,1yearand2yearsofexist—enceratedistinguishesfor100、89.7、85.3ingroupA,and85.2%、75.0%、61.5%ingroupB,respectively(P
7、IFUsupplementarytreatmentevaluatedandinstructedbyimmediatecontrast_enhancedul—trasoundforprimaryhepaticcarcinomacanhelptodestroythelesioncompletely,alleviatethesymptom,reduceecur—rence,improvelifequality,lengthenthelifetime,andhasbetterclinicalpracticevalue.Keywords:U1trasonogr