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1、授予單位代碼10089學(xué)號(hào)或申請(qǐng)?zhí)杋3852HebeiMedicalUniversity碩士學(xué)位論文在職科學(xué)學(xué)位EC-SOD在大鼠肝臟缺血再灌注損傷中的表達(dá)變化學(xué)位申請(qǐng)人：聶亞楠導(dǎo)師：王磊副教授專業(yè)：人體解剖與組織胚胎學(xué)二級(jí)學(xué)院：基礎(chǔ)醫(yī)學(xué)院2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識(shí)產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師(或指導(dǎo)小組)的指導(dǎo)下，由本人獨(dú)立完成。本學(xué)位論文研究所獲得的研究成果，其知識(shí)產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對(duì)本學(xué)位論文進(jìn)行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科大學(xué)，試驗(yàn)材料、原始數(shù)據(jù)、申報(bào)的專利等知識(shí)產(chǎn)權(quán)
2、均歸河北醫(yī)科大學(xué)所有。否則,承擔(dān)相應(yīng)法律責(zé)任。研究生簽名?本D導(dǎo)師簽章：二級(jí)學(xué)院領(lǐng)導(dǎo)蓋章：年《月S/日/河北醫(yī)科大學(xué)研究生學(xué)位論文獨(dú)創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果，除了文中特別加以標(biāo)注和致謝等內(nèi)容外，文中不包含其他人已經(jīng)發(fā)表或撰寫的研究成果，指導(dǎo)教師對(duì)此進(jìn)行了審定。本論文由本人獨(dú)立撰寫,文責(zé)自負(fù)卩研究生簽名淡4釁導(dǎo)師簽章：；>0-年月、丨曰目錄中文摘要·············································································1英文摘要·············
3、································································5研究論文EC-SOD在大鼠肝臟缺血再灌注損傷中的表達(dá)變化前言·············································································10材料與方法····································································11結(jié)果···································
4、··········································19附圖·············································································20附表·············································································27討論·············································································2
5、9結(jié)論·············································································30參考文獻(xiàn)·······································································30綜述氧化應(yīng)激、促氧化劑與抗氧化劑的研究進(jìn)展·······················33致謝···············································································
6、····44個(gè)人簡(jiǎn)歷·············································································45中文摘要EC-SOD在大鼠肝臟缺血再灌注損傷中的表達(dá)變化摘要臨床上在進(jìn)行肝臟手術(shù)如肝臟部分切除、肝臟移植以及處理嚴(yán)重肝臟外傷時(shí)往往需要暫時(shí)性阻斷肝臟血流一段時(shí)間后再重新恢復(fù)其血液供應(yīng)。在這個(gè)過(guò)程中就造成了肝臟的缺血再灌注損傷（hepaticischemiareperfusioninjury，HIRI）。HIRI是肝臟外科手術(shù)過(guò)程中一種常見(jiàn)的病理生理現(xiàn)象。肝臟的缺血再灌注可引起嚴(yán)重的肝細(xì)胞損傷
7、和肝功能障礙，這也是導(dǎo)致術(shù)后肝功能衰竭和病人預(yù)后較差的重要原因之一。研究已證實(shí)，導(dǎo)致這種損傷的主要機(jī)制之一為氧化應(yīng)激反應(yīng)。缺血再灌注時(shí)機(jī)體會(huì)產(chǎn)生大量活性氧自由基(reac-tiveoxygenspecies,ROS)。ROS包括超氧陰離子-(O2)、羥自由基(OH)和過(guò)氧化氫(H2O2)等。ROS的化學(xué)性質(zhì)非?；顫?，可以破壞細(xì)胞內(nèi)的蛋白質(zhì)、DNA和脂類等生物大分子，引起細(xì)胞死亡。超氧化物歧化酶（SuperoxideDismutases，SOD）是機(jī)體內(nèi)一種重要--的抗氧化酶，負(fù)責(zé)清除O2，它能將O2轉(zhuǎn)化成H2O2和氧，在機(jī)體抗氧化應(yīng)激反應(yīng)中具有重要作用。在哺乳動(dòng)
