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《yap與p-yap在肝細(xì)胞癌中的表達(dá)與其臨床生物學(xué)行為關(guān)系的研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、授予單位代碼10089學(xué)號(hào)或屮請(qǐng)?zhí)?3326HebeiMedicalUniversity碩士學(xué)位論文在職科學(xué)學(xué)位YAP與P-YAP在肝細(xì)胞癌中的表達(dá)與其臨床生物學(xué)行為關(guān)系的研究學(xué)位申請(qǐng)人：劉遠(yuǎn)光導(dǎo)師：李勇教授檀碧波副教授專業(yè)：外科學(xué)2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識(shí)產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師（或指導(dǎo)小組）的指導(dǎo)下，由本人獨(dú)立完成。本學(xué)位論文研究所獲得的研究成果，其知識(shí)產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對(duì)本學(xué)位論文進(jìn)行交流、公幵和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科大學(xué)，試驗(yàn)材料、原始數(shù)據(jù)、申報(bào)的專利等知識(shí)產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有。否
2、則，承擔(dān)相應(yīng)法律責(zé)任。河北醫(yī)科大學(xué)研究生學(xué)位論文獨(dú)創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果，除了文中特別加以標(biāo)注和致謝等內(nèi)容外，文中不包含其他人己經(jīng)發(fā)表或撰寫的研究成果，指導(dǎo)教師對(duì)此進(jìn)行了審定。本論文由本人獨(dú)立撰寫，文責(zé)自負(fù)。目錄中文摘要··············································································1英文摘要··············································································4英文縮寫
3、··············································································7研究論文YAP與P-YAP在肝細(xì)胞肝癌中的表達(dá)與其臨床生物學(xué)行為關(guān)系的研究前言··············································································8材料與方法·····································································9結(jié)果····················
4、·························································18附圖·············································································21附表·············································································27討論·······································································
5、······30結(jié)論·············································································33參考文獻(xiàn)·······································································34綜述YAP與惡性腫瘤的研究現(xiàn)狀與進(jìn)展····································37致謝······································································
6、·············46個(gè)人簡(jiǎn)歷·············································································48中文摘要YAP與P-YAP在肝細(xì)胞癌中的表達(dá)與其臨床生物學(xué)行為關(guān)系的研究摘要目的：肝細(xì)胞癌（HCC,hepatocellularcarcinoma）是肝臟原發(fā)腫瘤中最常見的類型，也是我國(guó)乃至全世界.最常見的惡性腫瘤疾病之一。通常HCC被發(fā)現(xiàn)時(shí)患者已進(jìn)入晚期，常規(guī)化療對(duì)其作用不明顯，致使生存率較其它癌癥顯著降低。因此，加強(qiáng)對(duì)HCC的發(fā)病機(jī)制研究，尋找更多關(guān)于肝癌基因及抑癌基因的表達(dá)并明確其與
7、HCC的關(guān)系已成為當(dāng)前研究的重要方向。Hippo通路在促進(jìn)細(xì)胞凋亡，限制細(xì)胞增殖，調(diào)控器官分化方面起著重要的作用。YAP(Yes-associatedprotein)即Yes相關(guān)蛋白，作為該通路下游的效應(yīng)因子，多以磷酸化形式（P-YAP）參與細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)以調(diào)控細(xì)胞凋亡與增殖的平衡。在病理狀態(tài)下，被阻斷或失活的Hippo通路對(duì)YAP磷酸化作用失效致YAP自身活性增強(qiáng)使細(xì)胞增生和凋亡間平衡失調(diào)、組織器官過度生長(zhǎng)及腫瘤發(fā)生。國(guó)內(nèi)外相關(guān)研究表明，YAP作為新近發(fā)現(xiàn)的癌基因，參
