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3、,為i1--;爾\S.鱗.N,?、.r咖’^氣‘:,,.,‘r’;.>私.Classificationcode:S853.74Universitycode:10712UDC:615Postgraduatenumber:2012053235Confidentialitylevel:PublicityThesisforMaster’sDegreeNorthwestA&FUniversityin2015STUDIESONPHARMACODYNAMICSOF“BAIBINGWUYOUOINTMENT”Type:Ma
4、sterofProfessionalDegreeinVeterinaryMedicineResearchfield:BasicVeterinaryMedicineNameofPostgraduate:Ying-huaHuangAdviser:Prof.Yin-qianLiDateofsubmission:November2015YanglingShaanxiChina“百病無(wú)憂膏”的藥效學(xué)研究摘要目的:中藥既能防治各種動(dòng)物的疾病,還能在動(dòng)物的個(gè)體發(fā)育中促進(jìn)動(dòng)物的生長(zhǎng),還可完善飼草料營(yíng)養(yǎng)性。近年來(lái),人們對(duì)中草藥的研究越來(lái)越多,其藥理作用受到人們廣泛關(guān)注。本研究對(duì)“
5、百病無(wú)憂膏”的藥效學(xué)進(jìn)行了研究,為今后“百病無(wú)憂膏”在獸醫(yī)臨床的開(kāi)發(fā)應(yīng)用提供理論依據(jù)。方法:通過(guò)建立二甲苯致小鼠耳殼腫脹模型、醋酸腹腔注射致小鼠疼痛模型、家兔骨折模型,觀察了“百病無(wú)憂膏”的抗炎、鎮(zhèn)痛、促進(jìn)骨折愈合作用效果。結(jié)果:(1)統(tǒng)計(jì)學(xué)分析表明,阿司匹林組和“百病無(wú)憂膏”組均與空白組差異顯著(P<0.05),而阿司匹林與“百病無(wú)憂膏”之間差異不顯著(P>0.05),說(shuō)明“百病無(wú)憂膏”具有明顯的抗炎作用;(2)小鼠腹腔注醋酸,“百病無(wú)憂膏”組的鎮(zhèn)痛率為100%(8/8),阿司匹林組的鎮(zhèn)痛率為75%(6/8);(3)X線和組織切片觀察都表明給藥組骨折愈合情況好
6、于空白組,且骨折愈合情況良好。結(jié)論:“百病無(wú)憂膏”具有抗炎、鎮(zhèn)痛、促進(jìn)骨折愈合的作用。關(guān)鍵詞:中草藥;百病無(wú)憂膏;耳殼腫脹模型;骨折模型;藥效學(xué)STUDIESONPHARMACODYNAMICSOF“BAIBINGWUYOUOINTMENT”ABSTRACTObjective:Chineseherbalmedicinehasadualroleofindividualandgroup,itcanpreventandcontrolanimalepidemic,andpromoteanimalgrowth,alsoimprovethefeednutrition.Inr
7、ecentyears,manypharmacologicaleffectsofChineseherbalmedicinewerepaidcloseattentionbythepeople.Theaimofourstudyistoobservepharmacodynamicsof“BaibingWuyouOintment”soastooffertheoreticalbasisforthedevelopmentandapplicationofthe“BaibingWuyouOintment”intheveterinaryclinicalofthefuture.Met
8、hod:Threemod