腫瘤標(biāo)志物聯(lián)合檢測在胃癌診斷中的應(yīng)用價(jià)值 畢業(yè)論文

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1、腫瘤標(biāo)志物聯(lián)合檢測在胃癌診斷中的應(yīng)用價(jià)值摘要目的：研究血清癌胚抗原（CEA）、糖類抗原199、（CA-199)、糖類抗原72-4（CA72-4）、糖類抗原（CA50)聯(lián)合檢測在胃癌診治中的臨床價(jià)值，以篩選理想的血清腫瘤標(biāo)志物組合，提高臨床診斷胃癌的靈敏度、診斷率。方法：應(yīng)用放射免疫分析（RIA）法和化學(xué)發(fā)光免疫分析法測定100例胃癌患者和46例非胃癌患者的血清中CEA、CA199、CA724、CA50四種腫瘤標(biāo)志物的含量，并分析單個(gè)腫瘤標(biāo)志物和五種標(biāo)志物聯(lián)檢對胃癌的敏感性和特異性結(jié)果：胃癌組CEA、CA199、CA724、CA50水平明顯高于非胃癌

2、組(P<0．05)、胃癌患者血清水平，CEA、CA199、CA724、CA50陽性表達(dá)率分別為52.00％、45.00％、47.00％、34.00％。聯(lián)合檢測陽性率為CEA+CA199=79%、CEA+CA724=76%、CEA+CA50=63%CA199+CA724=58%CA199+CA50=50%CA724+CA50=51%、CEA+CA199+CA724=88%、CEA+CA724+CA50=86%、CEA+CA199+CA50=83%、CA199+CA724+CA50=80%CEA+CA199+CA724+CA50=92%。兩者聯(lián)合檢測較

3、單一指標(biāo)陽性率高，三者聯(lián)合檢測普遍較兩者檢測陽性率高，四者聯(lián)合檢測普遍較三者聯(lián)合檢測陽性率高(P

4、DIAGNOSTICVALUEOFCOMBINEDDETECTIONWITHFOURTUMORMAKERFORGASTRICCANCERABSTRACTObjective:ToresearchtheclinicalsignificanceofserumtumormarkersCEA、CA199、CA724、CA50inthediagnosisofgastriccancer,tofiltertheidealserumtumormarkerscombination.SOastoimprovethesensitivityanddiagnosisratio

5、forgastriccarcinoma．Methods:TheserumconcentrationoftumormakersCEA,CA199,CA724,CA50intheserumof100patientswithgastriccancerand46healthyindividualsweremeasuredbyradioimmunoassay(RIA)andelectrochemiluminescencemethodMeanwhile，analyzingthedifferenceofasingletumormarkersandthecombi

6、neddetectionoffourtumormarkersinsensitivityandspecificityforthegastriccancer．Results:TheserumlevelsofCEA,CA125,CA199,CA724inpatientswithgastriccancerwereobviouslyhigherthanthoseinthecontrolgroupIthasstatisticalsignificance(P<0．05).TherespectivepositiveexpressionratesofCEA,CA19

7、9,CA724,CA50insumerare52.00％、45.00％、47.00％、34.00％．Thepositiveratesoftheunitetestofindexareasfollows,CEA+CA199is79.00%、CEA+CA724is76.00%、CEA+CA50is63.00%CA199+CA724is58.00%CA199+CA50is50.00%CA724+CA50is51.00%、CEA+CA199+CA724is88.00%、CEA+CA724+CA50is86.00%、CEA+CA199+CA50is83.00%

8、、CA199+CA724+CA50is80.00%CEA+CA199+CA724+CA50is92.00%。Theposi