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1、重慶醫(yī)科大學(xué)博士學(xué)位論文樹突狀細(xì)胞在小兒哮喘免疫發(fā)病機制中的作用研究姓名：蔣東波申請學(xué)位級別：博士專業(yè)：內(nèi)科學(xué)（小兒臨床免疫學(xué)）指導(dǎo)教師：周雅德;楊錫強2003.4.6重慶醫(yī)科大學(xué)博士研究生論文縮略語Antigenpresentingcells(APC)Dendriticcells(DCorDCs)Tumornecrosisfactor-alpha(n師一叻Granulocyte-macrophagecolonystimula-tingfactor(GM-CSF)Interleukin㈣Phosphatebufferso
2、lution(1aBS)Peripherialbloodmononuclearcells(PBMC)Majorhistocompatiblitycomplex(tvn-ic)Ethylenediamineteraceticacid(EDTA)CD40ligand(CD40L)Phycoetythdn(PE)Fluoresceinisothioeyanate(FITC)Langerhanscells(LC)Thelpertype1／2cells(Tm廠I證)GelatinNylonwoolTrypanblue(Tnfiat
3、edthymidine)3H-TdRNaiveTcellsCC·chemokinereceptor(CCR)V砒ueoffluorescence(VOF)Stimulateindex(SD抗原提呈細(xì)胞樹突狀細(xì)胞腫瘤壞死因子．0c粒巨細(xì)胞集落刺激因子白細(xì)胞介素磷酸緩沖液外周血單個核細(xì)胞主要組織相容性復(fù)合物乙二胺四乙酸CD40配體藻紅阮熒光素異硫氰酸熒光素朗格罕斯細(xì)胞輔助T淋巴細(xì)胞1或2亞群(型)明膠尼龍毛臺盼藍(lán)染液氚標(biāo)記的胸腺嘧啶核苷初始型T淋巴細(xì)胞CC趨化因子受體熒光密度刺激指數(shù)重慶醫(yī)科大學(xué)博士研究生論文縮略語Enzym
4、e—linked(ELISA)Ficoll·Hypaqueimmunosor-bentassay酶聯(lián)免疫吸附測定NaiveCD4+Tcells(Tm)Airwayhyperreactivity(AHR)AirwayallergicinflammationInterferon(羽N)Interferon-y(IFN·Y)Transforminggrowthfactor(TGF)Transforminggrowthfactor-beta(TGF—beta)FlowcytometryanalysisMonocyte-deriv
5、edDCs(MDC)AllergicbronchialasthmaLipopolysaccharidcaLPS)PhytohaemagglutininO'HA)Intercellularadhesionmoleeule-10CAM一1)Majorbasicprotein0vme)Eosinophilcationicprotein(ECP)Platelet-aetivatingfactor㈣Lcukotrienes(∽Eosinphilicchemotacfactor(ECF)Neu舡Dpllilchemomcticfac
6、tor州CF)Mixedlymphocytereaction(MLR)ProstaglandinE2(PGE2)聚蔗糖．泛影酸鈉淋巴細(xì)胞分離液TH前體細(xì)胞，裸CD4+T細(xì)胞氣道高反應(yīng)性氣道變應(yīng)性炎癥干擾素v·干擾素轉(zhuǎn)化生長因子轉(zhuǎn)化生長因子-B流式細(xì)胞分析單核細(xì)胞衍生的樹突狀細(xì)胞支氣管哮喘脂多糖植物血球凝集素細(xì)胞間粘附分子一l主要堿性蛋白嗜酸性粒細(xì)胞陽離子蛋白血小板活化因子白三烯嗜竣性細(xì)胞趨化因子中性粒細(xì)胞趨化因子混合淋巴細(xì)胞反應(yīng)前列腺素E2重慶蓬辯大學(xué)博士研究擻論文縮略語Co—stimulatorymoleculesSi
7、gnaltrangduc8andactivatoroftranscription,STATT-boxexposedinTcells(T-bet)Zinc-fingertranscriptionfactor(GATA·3)IFN-yinducmgfactor(ILqS)Signaltransdttcerfactor(STF)JanusKinascJAKBasicregionrleucinezipper,(c-ma0Immunoglobulin(鞫CytotoxicT-lymphocyteantigen(CT漁-4)T-ee
8、Uantigen糟c吣(TCR)Nuclearfactor[kappa]B(NF-1cB)Inhibitory[kappa]Bproteing-IcB)EosinophilicinflammationEpithelialfactors(aspGE∞Induciblecostimulatorymolecule,OCOs
