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1、中山大學(xué)碩士學(xué)位論文經(jīng)支氣管鏡肺活檢對周圍型肺癌的診斷價(jià)值中山大學(xué)附屬第二醫(yī)院同等學(xué)力研究生導(dǎo)師內(nèi)科學(xué)(呼吸系病)唐文輝李建國教授中文摘要目的評價(jià)經(jīng)支氣管鏡肺活檢(TBLB)對周圍型肺癌的診斷價(jià)值。方法分析78例周圍型肺癌,經(jīng)支氣管鏡常規(guī)檢查無法觀察到病變,采用經(jīng)支氣管鏡肺活檢,經(jīng)病理學(xué)或細(xì)胞學(xué)檢查證實(shí)42例。對于經(jīng)支氣管鏡肺活檢未獲得診斷的36例周圍型肺癌患者,其中22例通過CT引導(dǎo)下經(jīng)皮肺活檢(PNLB)證實(shí),另外14例患者依次經(jīng)外科手術(shù)、淋巴結(jié)活檢、胸膜活檢、胸水細(xì)胞學(xué)檢查等獲取標(biāo)本,經(jīng)病理學(xué)或細(xì)胞學(xué)檢查證實(shí),并對比分析TBLB和PNLB各自并發(fā)癥發(fā)生率及安全性,目的
2、在于評估TBLB對周圍型肺癌的陽性診斷率及安全性和可行性。結(jié)果已經(jīng)病理學(xué)或細(xì)胞學(xué)確診為肺癌78例,經(jīng)支氣管鏡肺活檢、刷檢的陽性率分別為53.8%、8.9%,聯(lián)合后總陽性率為57.7%;2種取材方法中,以TBLB的陽性率最高,與刷檢相比,差異有統(tǒng)計(jì)學(xué)意l義(尸2cm,陽性診斷率60.6%(37/61),兩組比較差異有統(tǒng)計(jì)學(xué)意義(仁O.022)。右肺活檢陽性率60%,左肺活檢陽性率45.5%,右肺高于左肺,兩組差異無統(tǒng)計(jì)學(xué)意義(P:-0.203);兩下葉活檢陽性率58%
3、,兩上葉活檢陽性率41.2%,下葉高于上葉,兩組差異無統(tǒng)計(jì)學(xué)意義(P:-0.229)。病例越靠近肺內(nèi)帶和肺門,TBLB的活檢陽性率越高。TBLB檢查過程出現(xiàn)咯血15例,無1例出現(xiàn)氣胸。PNLB并發(fā)癥發(fā)生率為40.9%,高于TBLB的19.O%,經(jīng)統(tǒng)計(jì)學(xué)檢驗(yàn),認(rèn)為兩組并發(fā)癥發(fā)生率差異有統(tǒng)計(jì)學(xué)意義(P=-0.012)。結(jié)論經(jīng)支氣管鏡肺活檢檢查是確診周圍型肺癌的重要手段之一,聯(lián)合應(yīng)用多種取材方法和技術(shù)可提高周圍型肺癌的診斷準(zhǔn)確率。關(guān)鍵詞支氣管鏡術(shù)肺活檢周圍型肺癌診斷¨中山大學(xué)碩士學(xué)位論文Diagnosticvalueoftransbronchiallungbiopsy●l_lin
4、peripherallungCancerDepartmentofMedicine(RespiratoryDisease)The2ndHospitalAttachedtoZhongshanUniversityMasterpostgraduate:TangWenhuiSupervisor:ProfessorLijianguoAbstractObjectiveToevaluatediagnosticvalueoftransbronchiallungbiopsy(TBLB)inperipherallungcancer.MethodsTransbronchiallungbiopsy(
5、TBLB)wereperformedin78casesofperipherallungcancerwhichcouldnotbeobservedbybronchoscope,and42casesamongthemwerediagnosedbypathologyandcytologicexamination.36casesofperipherallungCanCerwerenotabletobediagnosedbyTBLB,and22casesamongthemwerediagnosedbypercutaneouslungbiopsy(PNLB),and14casesbei
6、ngleftwerediagnosedbysurgicaloperation,lymphadenopathybiopsy,pleurabiopsyandsputumcytologicexaminationsuccessively.ComplicatinratesandsecurewereidentifiedinTBLBandPNLB.ResultsThepositiverateproducedbytransbronchiallungbiopsy,brushbiopsywere53.8%and8.9%respectively.ThetotalpositiveIII中山大學(xué)碩士
7、學(xué)位論文ratewas57.7%.ThepositiverateproducedbyTBLBwashigherthanthatofbrushbiopsy(尸/2cm)Was60.6%(37/61).Thepositiverateofrightlung(60%)washighertha