資源描述：
《T細(xì)胞活化的分子機(jī)制 2014碩士》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、T細(xì)胞活化機(jī)制何睿ruihe@fudan.edu.cn免疫學(xué)系上海醫(yī)學(xué)院復(fù)旦大學(xué)BasedonthehistoryofantigenencounterandthestageofTcellactivation.?Na?veTcells?MatureTcellsthathavenotpreviouslyencounteredantigen;?Preferentialmigrationtosecondarylymphoidorgans(lymphnodes),wheretheyrecognizeantigen?EffectorTcells?Activa
2、tedTcellscapableofperformingthefunctionsrequiredtoeliminateforeignantigens?Preferentialmigrationtositesofinfectionorinflammation?Short-lived?MemoryTcells?Long-lived,functionallysilentcells;?Mountrapidsecondaryimmuneresponsestothesameantigenexposure?Heterogenous(centralandeffe
3、ctor)外周淋巴器官內(nèi)抗原識(shí)別應(yīng)答誘導(dǎo)T細(xì)胞擴(kuò)增和分化分化的細(xì)胞進(jìn)入循環(huán)效應(yīng)T細(xì)胞和其他白細(xì)在外周效應(yīng)T細(xì)胞胞遷移到感染部位遭遇抗原效應(yīng)T細(xì)胞活化T細(xì)胞的效應(yīng)功能ActivationofTcellschangestheexpressionofseveralcell-surfacemolecules.FunctionalresponsesofTcells?Secretionofcytokines?Proliferation?DifferentiationintoeffectorTcells?DifferentiationintomemoryTce
4、llsSecretionofcytokines?OneoftheearliestdetectableresponsesofTcellstoantigenrecognition?Principlecytokine:IL-2?DistinctsetsofcytokinessecretedbyeffectorTcellsClonalexpansionofTcellsAntigen-presentingcellsarerequiredforTcellactivationTheinitiationofTcellresponsestospecificanti
5、genrequires?SpecificantigenrecognitionbytheTcells;?StableadhesionoftheTcellstotheAPCs;?TransductionofactivatingsignalstotheTcells.EachoftheseeventsismediatedbydistinctsetsofmoleculesontheTcells.TcellreceptorsandaccessorymoleculesTcellreceptor(TCR)ThedefinitiveTcelllineagemark
6、er?RecognitionofMHC-associatedpeptideantigenDualspecificity?MHCrestriction?Antigenspecificity?Nosignal-transducingfunctionsTCRcomplexComposedofTCRandCD3proteinCD3?invariantprotein,identicalinallTcellsregardlessofspecificity?responsibleforsignaling,butnotantigenrecognitionImmu
7、noreceptortyrosine-basedactivationmotif（ITAM)?Containstwocopiesofaconservedsequence:tyrosine-X-X-leucine/isoleucine?ImportantforsignaltransductioninTcellsAntigenrecognitionandsignalingfunctionsofTcells?Antigenrecognition?SignalingfunctionsCo-receptorsAcategoryofmembraneprotei
8、nsthatenhanceTCRsignalingthroughsimultaneousbindingoftheMHCmolecules
