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1、神經(jīng)系統(tǒng)疾病DiseasesofNervousSystem引言神經(jīng)系統(tǒng)的功能和結(jié)構(gòu)中樞神經(jīng):腦、脊髓、腦脊膜腦實(shí)質(zhì):灰質(zhì)和白質(zhì),腦室:腦脊液神經(jīng)元(神經(jīng)纖維)、膠質(zhì)細(xì)胞(膠質(zhì)纖維)小膠質(zhì)細(xì)胞周圍神經(jīng):神經(jīng)纖維、髓鞘、神經(jīng)膜植物神經(jīng):神經(jīng)節(jié)cerebellumBetzcellNissl小體引言神經(jīng)系統(tǒng)疾病的特點(diǎn)定位與定性:1)病變定位與功能障礙之間關(guān)系密切2)相同病變?cè)诓煌课怀霈F(xiàn)不同后果對(duì)致病因子的病理反應(yīng)較單一:1)需熟悉基本病變2)與臨床關(guān)系密切解剖生理特征的雙重影響:合并癥引言神經(jīng)系統(tǒng)疾病的分類VascularD.血管疾
2、病Infections感染Tumors腫瘤Trauma創(chuàng)傷Malformations.畸形DegenerativeD.變性疾病DemyelinativeD.脫髓鞘疾病MetabolicD.代謝性疾病…...§1Basicreactionstoinjury對(duì)損傷的基本反應(yīng)§2Commoncomplications常見并發(fā)癥§3Infections§4CJD§5Alzheimer’sD.(老年性癡呆)§6Tumors§1BasicpathologicchangesNeuronDegeneration變性、Necrosis壞死神經(jīng)細(xì)
3、胞脫失(Loss)液化性壞死軸索和髓鞘的變化(Wallerdegeneration)Centralchromatolysis中央性Nissl小體溶解Redneuron紅色神經(jīng)細(xì)胞神經(jīng)原纖維纏結(jié)NeurofibrillarytanglesGhostcell鬼影細(xì)胞WallerdegenerationWaller變性WallerdegenerationSudan§1BasicpathologicchangesNeurogliaHypertrophy肥大Proliferation增生Astrocytes:膠質(zhì)瘢痕(gliosis)、
4、Oligodendrocyte:衛(wèi)星現(xiàn)象(satellitosis)InterfasclcularoligodendrogliaPerineuronalsatelliteoligodendroglia§1BasicpathologicchangesMicroglioExudation滲出Proliferation增生膠質(zhì)結(jié)節(jié)(glialnodule)噬神經(jīng)細(xì)胞現(xiàn)象(neuronophagia)格子細(xì)胞(latticecell)Microglialnodule膠質(zhì)結(jié)節(jié)Rodcelllatticecell格子細(xì)胞§1Basicpa
5、thologicchangesExudation滲出:充血水腫炎癥細(xì)胞、小膠質(zhì)細(xì)胞(Perivascularcuffing血管套)腫瘤性增生:§2CommoncomplicationsBrainedema腦水腫Hydrocephalus腦積水Increasedintracranialpressure顱內(nèi)壓升高Herniation腦疝合并癥I.Brainedema腦水腫Vasogenicedema血管源性腦水腫Cyotoxicedema細(xì)胞毒性腦水腫腦實(shí)質(zhì)組織中液體貯積過多分型:肉眼:W,V,腦回寬、腦溝窄,腦室縮小,Thesu
6、rfaceofthebrainwithcerebraledemademonstrateswidenedgyriwithaflattenedsurface.Thesulciarenarrowed.056腦水腫Vasogenicedema原因:毛細(xì)血管內(nèi)皮受損,血腦屏障發(fā)生障礙形態(tài):細(xì)胞外間隙及血管周隙擴(kuò)大,常見于:腦腫瘤、出血、創(chuàng)傷及炎癥腦水腫Cyotoxicedema原因:細(xì)胞能量代謝障礙,細(xì)胞內(nèi)鈉水潴留形態(tài):細(xì)胞腫脹,細(xì)胞內(nèi)水腫,常見于:缺血和中毒Neuronalvacuolation合并癥II.Hydrocephalus腦
7、積水常見于:先天性畸形,炎癥、外傷、腫瘤、出血等原因:腦脊液循環(huán)的通路被阻斷腦脊液產(chǎn)生和吸收異常腦脊液量增多伴腦室擴(kuò)張病變腦室擴(kuò)張,腦實(shí)質(zhì)變薄.嬰幼兒:囟門擴(kuò)大,骨縫分開.合并癥II.Hydrocephalus腦積水合并癥III.顱內(nèi)壓升高腦疝正常CSF壓:0.6~1.8kPa顱內(nèi)壓升高:2kPa(200mmH2O,15mmHg)原因:顱內(nèi)容物的容積增加結(jié)果:腦組織移位、嵌入----腦疝(Herniation)合并癥Herniation腦疝Cingulate/subfalcineherniation扣帶回疝(大腦鐮下疝)Unc
8、al/transtentorialherniation海馬鉤回疝(小腦天幕疝)Tonsillar/formenmagnumherniation小腦扁桃體疝(枕骨大孔疝)部分腦組織嵌入顱腦內(nèi)分隔處和顱骨孔道內(nèi)類型Cingulate/subfalcineherniation扣帶回