《細(xì)胞亞群》PPT課件

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1、T細(xì)胞亞群ClassesoflymphocytesT細(xì)胞亞群T細(xì)胞活化分子機(jī)制T細(xì)胞免疫應(yīng)答及其效應(yīng)自身免疫和超敏反應(yīng)Tcellsubsets??Tcellsand??TcellsCD4+TcellsandCD8+TNa?veTcells（初始T細(xì)胞）EffectorTcells（效應(yīng)T細(xì)胞）MemoryTcells（記憶T細(xì)胞）Thelper(Th)輔助性CD4+T細(xì)胞CytotoxicTcells(CTLs)細(xì)胞毒性CD8+T細(xì)胞RegulatoryTcells(Tregs)調(diào)節(jié)性CD4+T細(xì)胞TCellsubsetsClassFunctionsAnt

2、igenreceptorandspecificitySelectedmarkersPercentoftotallymphocytes(human)αβTlymphocytesBloodLymphnodeSpleenCD4+helperTlymphocytesBcelldifferentiation(humoralimmunity)Macrophageactivation(cell-mediatedimmunity)αβheterodimersDiversespecificitiesforpeptide-classIIMHCcomplexesCD3+,CD

3、4+,CD8-50-60*50-6050-60CD8+cytotoxicTlymphocytesKillingofcellinfectedwithmicrobes,killingoftumorcellsαβheterodimersDiversespecificitiesforpeptide-classIMHCcomplexesCD3+,CD4-,CD8+20-2515-2010-15RegulatoryTcellsSuppressfunctionofotherTcells(regulationofimmuneresponses,maintenanceofs

4、elf-tolerance)αβheterodimersCD3+,CD4+,CD25+(Mostcommon,butotherphenotypesaswell)Rare1010γδTlymphocytesHelperandcytotoxicfunctions(innateimmunity)γδheterodimersLimitedspecificitiesforpeptideandnonpeptideantigensCD3+,CD4,andCD8variable??TcellsexpressalimitednumberofTCRsabundantinepi

5、thelialtissuesofcertainspecies:inthesmallbowelmucosaandintheskinofmouse.Intheskin,knownasadendriticepidermalTcell(DETC)donotrecognizeMHC-associatedpeptideantigensandarenotMHCrestricted.maybindtoconservedligandswhoseexpressionistriggeredbycellinjuryorstress,suchasmicrobialheatshock

6、proteins.mayrepresentanimportantbridgebetweeninnateandadaptiveimmunity,functioningaslymphocytesthatenhancethefirstlineofdefenseagainstarangeofpathogens.Jensen,K.D.etal.Thymicselectiondetermines??Tcelleffectorfate:antigen-naivecellsmakeinterleukin-17andantigen-experiencedcellsmakei

7、nterferon?Immunity29,90–100(2008).Epithelial??TcellandPeripheral??TcellCD27-IL-17+??TcellsandCD27+IFN-?+??TcellsSubsetsof??TcellsDevelopmentalprogrammingof??Tcellsubsets.CuaDJ,etal.NaturereviewImmunology,2010MartinBetal.IL-17-Producing??TcellsSelectivelyExpandinResponsetoPathogenP

8、roductsandEnvironmentalSignals.Im