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1、InternationalJournalofNeuroscienceISSN:0020-7454(Print)1543-5245(Online)Journalhomepage:http://www.tandfonline.com/loi/ines20PotentialroleofgutmicrobiotaandtissuebarriersinParkinson'sdiseaseandamyotrophiclateralsclerosisXinFangTocitethisarticle:XinFang(2015):Potentialr
2、oleofgutmicrobiotaandtissuebarriersinParkinson'sdiseaseandamyotrophiclateralsclerosis,InternationalJournalofNeuroscience,DOI:10.3109/00207454.2015.1096271Tolinktothisarticle:http://dx.doi.org/10.3109/00207454.2015.1096271Acceptedauthorversionpostedonline:18Sep2015.Publ
3、ishedonline:16Oct2015.SubmityourarticletothisjournalArticleviews:136ViewrelatedarticlesViewCrossmarkdataFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=ines20Downloadby:[UniversityofWesternOntario]Date:08No
4、vember2015,At:13:10InternationalJournalofNeuroscience,2015;EarlyOnline:1–6Copyright?2015Taylor&FrancisISSN:0020-7454print/1543-5245onlineDOI:10.3109/00207454.2015.1096271ORIGINALARTICLEPotentialroleofgutmicrobiotaandtissuebarriersinParkinson’sdiseaseandamyotrophiclater
5、alsclerosisXinFangDepartmentofNeurology,TheFirstAffiliatedHospitalofNanchangUniversity,Nanchang,ChinaParkinson’sdisease(PD)andamyotrophiclateralsclerosis(ALS)areneurodegenerativediseaseswithpatho-physiologythatmayberelatedtothegastrointestinaltract.Itiswellestablishedt
6、hattissuebarriersmaintainhomeostasisandhealth.Furthermore,gutmicrobiotamayhaveanimpactonbrainactivitythroughthegut-microbiota–brainaxisunderbothphysiologicalandpathologicalconditions.Inthisreview,wehighlightthecur-rentknowledgeregardingtheroleofgutmicrobiotaandtissueba
7、rriersinPDandALS.Toourknowledge,thisisthefirstreviewofthekeyissuesinvolvingboththealteredgutmicrobiotaandimpairedtissuebarriersinthepathophysiologyofPDandALS.KEYWORDS:gutmicrobiota,Parkinsondisease,amyotrophiclateralsclerosisIntroductiondisease.Thisreviewpresentsthecur
8、rentknowledgere-gardingthegutmicrobiotainALSandPD.Parkinson’sdisease(PD)andamyotrophiclateralscle-Thegutmicrobiotacon
