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1、高血壓患者眼底改變的影響因素分析【摘要】目的分析高血壓患者發(fā)生眼底改變的影響因素,為高血壓性眼底改變的防治提供臨床參考。方法收集511例原發(fā)性高血壓患者,根據(jù)是否存在眼底病變分為眼底病變組357例和無眼底病變組154例。比較兩組患者收縮壓、血總膽固醇、甘油三酯、同型半胱氨酸濃度及尿蛋白水平,并對眼底病變程度與相關(guān)影響因素的關(guān)系進行分析。結(jié)果眼底病變組收縮壓2140mmHg>總膽固醇>5.17mmol/L>同型半胱氨酸>15Pmol/L及伴有蛋白尿的比例明顯高于無眼底病變組(P<0.05)o眼底病變程度隨收縮壓、總膽固醇、同型半胱氨酸、蛋白尿濃度的升高而加重,兩者呈正相
2、關(guān)。結(jié)論影響高血壓患者眼底改變的因素較多,收縮壓、血總服固醇、同型半胱氨酸及蛋白尿濃度是眼底改變較為顯著的影響因素,它們可能參與了高血壓患者眼底改變過程,高血壓早期密切監(jiān)測有利于預(yù)防眼底病變或減輕眼底病變程度。【關(guān)鍵詞】高血壓;眼底改變;小動脈痙攣;動脈粥樣硬化中圖分類號:R773.4;R544.1文獻標識碼:ADOI:10.3969/j.issn.10031383.2017.02.025[Abstract]ObjectiveToanalyzeinfluencingfactorsofocularfunduschangesinpatientswithessentidlh
3、ypertension,soastoprovideclinicalreferencefortheproventionandtroatmentofhypertension.Methods511patientswithessentialhypertensionwerecollected,accordingtopreseneeoffunduslesions,theyweredividedintofunduslesiongroup(357cases)andnonfunduslesiongroup(154cases)?Andthen,systolicbloodpressure,
4、serumtotalcholesterol,triglyceride,homocysteineandurinaryproteinlevelswerecomparedbetweenthetwogroups.Andtherelationbetweenthedegreeoffundusdiseasesandtherelatedfactorswasanalyzed.ResuItsTheproportionofsystoliebloodpressured140mmHg,totalcholesterol>5.17mmol/L,homocystcinc>15Pmol/L,combi
5、nedwithproteinuriainthefunduslesionsgroupweresignificantlyhigherthanthoseinthenonfunduslesiongroup(P<0.05).Thedegreeoffunduslesionsaggravatedwiththeincreaseofsystolicbloodpressure,totalcholesterol,homocysteineandproteinurineconcentration,whichshowedapositivecorrelation.ConclusionTherear
6、emanyfactorsaffectingfunduschangesinpatientswithhypertension,andpatient?ssystolicbloodpressure,serumtotalcholesterol,homocysteineandurineproteinconcentrationarethesignifica.ntones,theymayinvolveintheprocessoffunduschanges.Earlymonitoringofhypertensionisbeneficialtothepreventionofocularf
7、undusdiseasesoralleviatethedegreeofocularfundusdiseases.[Keywords]hypertension;funduschanges;smallarteryspasm;atherosclerosis高血?旱姆2?三縉誑芍氯?身小動脈病變,隨著病情的進展,血管管徑、管壁會出現(xiàn)各種病理改變,終致動脈粥樣硬化(AS)形成。高血壓早期可引起眼底小動脈痙攣和收縮,嚴重時可致視網(wǎng)膜水腫、滲血,甚至可造成高血壓性視神經(jīng)病變,影響患者視力[1]。因此,對高血壓患者發(fā)生眼底改變的危險因素進行分析,在疾病早期進行干預(yù)顯