MGMT表達(dá)與非小細(xì)胞肺癌化療療效和預(yù)后關(guān)系的研究

《MGMT表達(dá)與非小細(xì)胞肺癌化療療效和預(yù)后關(guān)系的研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。

1、B3中國(guó)肺僥雜志2UU3年2刀第6卷弟1期ChinJl.ungOinwr.Flbrunry2UU3.'oL6?No.IMGMT表達(dá)與非小細(xì)胞肺癌化療療效和預(yù)后關(guān)系的研究呂金芳劉茹李彬邱雪杉李慶昌王恩華【摘要】目的研究MGMT在非小細(xì)胞肺癌INSC'LO組織中的表達(dá)悄況及其lJNSCLC#化療療效和預(yù)后的關(guān)系。方法應(yīng)用免疫組化SF法檢測(cè)正常肺組織及腫瘤組織中的MGMT喪達(dá)。將128例7SCI.C組織分為Mcr組（MGMT表達(dá)陰性）和Mer"組（MGMT表達(dá)陽(yáng)性兒結(jié)果128例NS

2、6「128）?而10例正常肺紐織中未見(jiàn)MGMT表達(dá)。MGMT表達(dá)與肺癌患者性別.年齡、腫瘤分期、淋巴結(jié)轉(zhuǎn)移、組織類(lèi)型等臨床生理病理特征均無(wú)明顯關(guān)系.Mer組術(shù)肩平均生存期及生存率均較Mer'組明顯延長(zhǎng)（PV0.01?P<0.05）.45例可評(píng)價(jià)療效的病例中?Mcr組總的化療有效率為12.86%（921）.Mer'組為4.17%（1/24》（P<0.（）01）；Mcr組生存期和生存率明顯高于Mer，組tP<0.01?P

3、指標(biāo)?！娟P(guān)鍵詞】非小細(xì)胞肺癌MGMT化療【中圖分類(lèi)號(hào)】R73.3MGMTexpressionanditsrelationshipwithefficacyofchemotherapyandprognosisinpatientswithnon-smallcelllungcancerlAJJinJcuig*?LIURu?I」Bin?QIUXueshun9LIQin^chan^?WANGEnhua?*Departmeritof(^icologyMedicine?Anshunthe4thHospital.Anshun.

4、Liaoning114033?P.R.China.(Abstract]ObjectiveTostudytheexpressionofMGMTanditsrelationshipwithefficacyofchemotherapyandprognosisinpatientswithnon-smallcelllungcancer(NSC'IA)?MethodsMGMIwasdetectedin128MSCLl、tissuesand10normalpulmonarytissuesbyimnHinohistochc

5、mistry.AccordingtothelevelofMCjMT.128patientswithNSC'Ll'weredividedintothegroupMerwiihnegativeMGMTexpressionandthegroupMerwithpositiveMGMTexpression.ResultsMCiMTpositivelyexpressedin61of128patientswithNSC'IA'(47.66>zo)?hutnoneofnormalgroup.Nosignificantrela

6、tionshipwasfoundamongM(；MTexpressn沁nandTNMstages,lymphnodemetastasisandhistologicalclassificationofthecancer.However,(hemeansurvivalperiodsandsurvivalratesingroupMerweresignificantlyhigherthanthoseofgroupMer"(PV0.01?P<0.05).In45evaluablepatients^totalrespon

7、seraleswere42.Sb%andI.17%inMerandMer"patientsrcspvctively(P<0.001):andtherewereremarkablylongermeansurvivalperiodsandhighersurvivalratesinMerpatientsthanthoseinMer"patients(P<0.01?P

8、pyandprognosisinpatientswithNSt'LC.[Keywords]NSCLCMGMTChemotherapyThisworkwassupportedbyagrantfromtheScientificFundofAn?*hanScienceCommittee?LiaoningProvinceofChinaItoLUJinfang)(No.2001283).腫瘤細(xì)胞耐藥是部分患者