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1、利培酮聯(lián)合丙戊酸鈉用于躁狂發(fā)作急性期治療的臨床研究【摘要】目的研究利培酮聯(lián)合丙戊酸鈉用于躁狂發(fā)作急性期治療的安全性和有效性。方法97例躁狂發(fā)作急性期患者作為研究對象，隨機分為試驗組和對照組。試驗組采用丙戊酸鈉聯(lián)合利培酮治療，對照組采用丙戊酸鈉治療，觀察6周，通過Bech-Rafaelsen躁狂量表評價有效性，并觀察用藥安全性。結果兩組患者均順利治療，無一例脫落。治療后6周，試驗組臨床治療總有效率X87.8%,與對照組的85.4%比較，差異無統(tǒng)計學意義。治療前兩組BRMS評分比較差異無統(tǒng)計學意義。兩組治療后1、2、4、
2、6周末BRMS評分均逐漸降低，均低于治療前。研究組治療后1、2、4周末BRMS評分低于對照組，差異有統(tǒng)計學意義;兩組治療后6周末BRMS評分比較差異無統(tǒng)計學意義。兩組患者不良反應主要為輕度和中度，可耐受，經(jīng)過相應處理后不良反應緩解，試驗組不良反應發(fā)生率為24.5%,與對照組的22.9%比較，差異無統(tǒng)計學意義。結論治療急性躁狂癥患者應用利培酮聯(lián)合丙戊酸鈉，能夠縮短起效時間，安全有效?！娟P鍵詞】躁狂發(fā)作；利培酮；療效；安全性DOI：10.14163/j.cnki.ll-5547/r.2017.16.018Clinical
3、researchofrisperidonecombinedwithsodiumvalproateinthetreatmentofacuteperiodofmanicepisodeQINQiu-hong,JIANGTao.BeijingHuairouAnjiaHospital,Beijing101408,China【Abstract】ObjectiveToresearchsafetyandeffectivenessbyrisperidonecombinedwithsodiumvalproateinthetreatmen
4、tofacuteperiodofmanicepisode?MethodsAtotalof97patientswithacuteperiodofmanicepisodeasstudysubjectswererandomlydividedintoexperimentalgroupandcontrolgroup.Theexperimentalgroupreceivedrisperidonecombinedwithsodiumvalproatefortreatment,andthecontrolgroupreceivedso
5、diumvalproatefortreatment.After6-weekobservation,Bech-Rafaelsenmaniaratingscalewasusedtoevaluateeffectinessinpatients,andtheirmedicationsafetywasobserved?ResultsBothgroupsreceivedsuccessfultreatment,withoutanyfall-offcase.In6weeksaftertreatment,theexperimentalg
6、rouphadtotaleffectiverateinclinicaltreatmentas87.8%,whichwas85.4%inthecontrolgroup,andtheirdifferencehadnostatisticalsignificance?TherewasnostatisticallysignificantdifferenceofBRMSscorebetweenthetwogroupbeforetreatment?Attheendof1,2,4,6weeksintreatment,bothgrou
7、pshadgraduallylowerBRMSscoresthanthosebeforetreatment?TheexperimentalgrouphadalllowerBRMSscoreattheendofL2,4weeksintreatmentthanthecontrolgroup,andthedifferencehadstatisticalsignificance?ThedifferenceofBRMSscoreattheendof6weeksintreatmentbetweenthetwogroupshadn
8、ostatisticalsignificance?Bothgroupsshowedtolerablemildandmoderateadversereactions?whichwererelievedaftercorrespondingtreatment.Theexperimentalgrouphadincidenceofadversereact
