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1、延邊大學碩士學位論文延邊地區(qū)慢性丙型肝炎患者血清中口身抗體的檢測及其臨床意X姓名:許順姬中請學位級別:碩士專業(yè):生理學指導教師:金元哲20070530英文縮略寫縮略詞英文全稱中文全稱ACLanti-cardiolipinantibody抗心卵磷脂抗體AIH-1autoimmunehepatitis自身免疫性肝炎J型ALTalanineaminotranseferase丙氨酸氨基轉移酶ALBalbumin白蛋白ANAanti-nuclearantibody抗核抗體AMAanti-mitochedridantibody抗線粒體抗體ASAanti-smoothmus
2、cleantibody抗平滑肌抗體ASTaspartatearrunotranseferase天門冬氨酸轉移酶HBsAgHepatitisBVirusSantigen■乙型肝炎病毒HCVViralhepatitisC丙型肝炎病毒HCV-RNAViralhepatitisC-RNA丙型肝炎病毒-核糖核酸際臨床化學聯(lián)合會IFCCIntematyionalFederationofClinicalChemistryIIFIndirectImmunofluorescenceAssye間接免疫熒光法IFNInterference干擾素RFRhenmatoidFactor類
3、風濕因子目的:分析延邊地區(qū)慢性丙型肝炎患者血清中自身抗體陽性率及其臨床意義。方法:選擇100名慢性丙型肝炎患者(慢性肝炎79例,肝硬化21例),檢測自身抗體(ACL,ANA,ASA,AMA,RF)陽性率,并比較自身抗體(+)及自身抗體(?)群年齡.性別、肝功能狀態(tài)。結果:慢性丙型肝炎患者血清中自身抗體至少一種陽性的62例。ACL陽性40例最多,其次為ANA陽性29例,RF陽性19例,ASA陽性8例,AMA陽性3例。另外,自身抗體陽性組和陰性組有關因素比較發(fā)現(xiàn),自身抗體陽性組較陰性組年齡大(58.7歲V549.7歲)、女性多見(79?2%w46.2%)、肝功能狀
4、態(tài)及肝病狀態(tài)差。結論慢性丙型肝炎血清中常出現(xiàn)自身抗體,自身抗體出現(xiàn)可影響肝功能狀態(tài),加重病情,在臨床診療中應慎重。關鍵詞:延邊地區(qū):自身抗體:丙型慢性肝炎;Abstract:FDetectionandclinicalsignificanceofautoantibodiesinserumofpatientswithchronicHepatitisCinYanbianareaAIM:ToanalyzethepositiverateofautoantibodiesinpatientswithchronicchronicHepatitisCandtheirclini-
5、calsignifi■cances.METHODS:Thepositiverateofautoantibodiesincludinganti-cardiolipin(ALC),anti-nuclear(ANA),an-tismoothmuscle(ASA),anti-mitochondrial(AMA)an-tibodies,andrheumatiodfactor(RF)weredetectedin100patientswithchronicHepatitisC(79chronichepatitisC,21live.cirrhosis)?Andthefacto
6、rssuchasage,gender,andliverfunction,betweenpatientswithautoantibodiespositiveandnegativewerecompared.RESULTS:Theoverallpositiverateoftheautoanti-bodieswas62.0%.ThepositiverateofACL,ANA,RF,ASA,andAMAwas40.0%,29.0%,19.0%,8.0%,and3.0%,respectively.Ascomparedwiththeautoantibody-negative
7、patients>theautoantibody-positivepatientshepatitisC,21livercirrhosis)?Andthefactorssuchwereorder(5&7vs49.7),andwithworseliverfunctionanddiseasestatus.Thepositiveexpressionofautoan-tibodywasfoundhigherinfemalesthanthoseinmales(79.2%vs46.2%).CONCLUSION:Theautoantibodiesarecommonlyfoun
8、dinpatientswithchro